摘要
子宫内膜容受性是指子宫内膜对胚胎的接受能力,只有处于容受期的内膜才允许胚泡黏附侵入。而容受期的建立和维持受很多分子及基因的调控,近年来微小RNA(miRNA)对子宫内膜容受性的调控作用日益受到关注。多个研究利用高通量表达分析的手段分析了自然月经周期和超促排卵周期等不同容受状态的子宫内膜,发现miRNA均表现出特征性的表达变化,初步揭示了miRNA作为子宫内膜容受性标记物的潜力。作为调节基因表达的转录后调节因子,miRNA对子宫内膜容受性的调节主要体现在对与容受性相关的关键基因和通路的表达调节上。
The endometrial receptivity is a temporal status of endometrium which posses the receptive ability to embryonic implantation. Only in the receptive phase,the endometrium allows embryo to attach and penetrate. It is regulated by many factors and genes to establish and maintain the endometrial receptivity. Recently,there is a growing interest in the role of microRNAs （miRNAs） in regulating the endometrium receptivity. With the high-throughout expression analytical methods,several studies have found some characteristics of miRNAs expressed in the endometrium of different receptive status,including the natural menstrual cycle and the stimulated cycle. Those preliminary results showed miRNAs as potential markers of the endometrium receptivity. As important post-transcriptional regulators of gene expression,miRNAs exert their functions through regulating the expression of key genes and pathways involved in the embryo implantation.
出处
《国际生殖健康／计划生育杂志》
CAS
2014年第1期52-55,共4页
Journal of International Reproductive Health/Family Planning
基金
厦门市重大科技平台项目(3502Z20111006)
2008年度军区医学科技创新课题项目(08MA068)
