摘要
目的：观察高血压患者血浆降钙素基因相关肽（ＣＧＲＰ）水平及与心钠素（ＡＮＰ）、内皮素（ＥＴ）、胰岛素（ＩＮＳ）之间相关性。方法：采用放射免疫法对６５例原发性高血压和５６例正常对照组者的血浆ＣＧＲＰ、ＡＮＰ、ＥＴ、ＩＮＳ水平进行测定分析。结果：高血压组ＣＧＲＰ水平降低（Ｐ＝０．０６７），男性高血压降低更为明显（Ｐ＜０．０５）。ＡＮＰ水平高于对照组（Ｐ＜０．０５）。ＥＴ水平两组无显著性差异。ＣＧＲＰ与ＥＴ之间呈正相关（Ｐ＝０．００５８），ＣＧＲＰ与ＡＮＰ、ＩＮＳ之间无明显相关性（Ｐ＞０．０５）。ＳＢＰ与ＡＮＰ之间呈正相关（Ｐ＝０．０３２９）。结论：高血压患者ＣＧＲＰ水平降低，其作用比ＥＴ水平变化更为明显。ＡＮＰ水平与高血压程度有关。
Objective: To investigate plasma contents of calcitonin gene related peptide (CGRP) in patients with hypertension and the correlation with endothelin (ET), atrial natriuretic peptide (ANP), insulin (INS) in these patients. Methods: Sixty five patients with essential hypertension (Ⅰ-Ⅱ phase, average age 55.4y)and 56 controls (average age 52.2y) were enrolled. Serum CGRP, ET, ANP, INS were determined by radioimmunoassay. Results: 1.CGRP content in patients were decreased comparing with controls (68.17±35.24,82.34±41.36,P=0.067), and it was significantly decreased (65.20±30.21,86.69±46.64;P<0.05) in male patients. 2. There were significantly positive relationship between CGRP and ET (r=0.2501,P=0.0057), between ANP and SBP (r=0.1941,P=0.0329). There were no significantly relationship among CGRP, ANP and INS (P>0.05).Conclusions: 1.Decreasing of plasma CGRP content may play a more important role than ET in pathogenesis and pathophysiologic process of essential hypertension. 2.Increasing of ANP in hypertension is a compensation.
关键词
高血压
内皮素
相关性
心钠素
CGRP
hypertension
calcitonin gene related peptide
endothelin
atrial natriuretic peptide
