摘要
高血压心功能不全患者血浆内皮素和心钠素含量变化汤大鸣１＊洪秀芳２史政萍２左希奎２（１．新疆维吾尔自治区人民医院起搏与介入中心，乌鲁木齐８３０００１２．新疆医学院第一附属医院核医学科乌鲁木齐８３００５４）ＣｈａｎｇｅｓｏｆＥｎｄｏｔｈｅｌｉｎａｎｄＡｔ...
AimToinvestigateplasmacontentsofendothelin(ET)andatrialnatriureticpep
tide(ANP)inhypertensionpatientswithcardiacinsufi-ciency.MethodsSevent
yfivecardiacinsufi-canceswith18inclassⅠ,37inclassⅡ,14inclassⅢ
and6inclassⅣ
werestudied.ETandANPweredeterminedbyradioimmunoassay.ResultsComparedw
ithcontrolgroup,theplasmacontentsofETandANPinpatientswithhypertension
increasedsignificantlyandcorelationbetweenthemsuggestedapositiverelat
ionship(P<0.01).Theplasmacon-tentsofETandANPofpatientswithcardiacfunc
tionclassⅠ
increasedsligntly(P>0.05),whilethoseofpatientswithcardiacfunctionclas
sⅡ,Ⅲ,Ⅳ
increaseddistinctlywithasignificantdiferenceamongclasses(P<0.01).Ther
ewereasignificantlypositivere-lationshipbetweenETandANPandleftventric
ularmassindexinalpatients.ConclusionEndothelinmayparticipatedinthepat
hogenicandpathophysi-ologicprocessofcardiacinsuficiencyinhyperten-sio
n.TheincreasingofANPsynthesisandsecretionunderthehypertensiveconditio
nhadanimportantcompensatoryandregulatorysignificance.
出处
《高血压杂志》
CSCD
1996年第4期268-270,共3页
Chinese Journal of Hypertension
关键词
高血压
心功能不全
内皮素
心钠素
hypertension
cardiacinsuficiency
endothelin
atrialnatriureticpeptide
