摘要
目的:探讨异甘草酸镁对肝切除术后肝功能的保护作用.方法:肝切除病例64例,随机分为试验组和对照组,试验组手术开始时给予异甘草酸镁150mg,术后连续用药7d,对照组为空白对照.分别于术前和术后1、3、7d测定空腹外周静脉血清ALT、AST、TBIL、DBIL、GGT、ALP的含量.结果:试验组术后ALT、AST(除了第3天)明显低于对照组(P<0.05或0.01),至术后第7天时,试验组有20例患者的血清ALT水平降至正常(64.5%),试验过程中未出现假性醛固酮症等不良反应.结论:异甘草酸镁可降低肝切除术后肝酶尤其是血清转氨酶的急剧增高,减少并发症的发生,适合在肝脏围手术期使用.
AIM：To investigate the protective effects of magnesium isoglycyrrhizinate on liver function in patients after liver resection.METHODS：Sixty-four patients undergoing liver resection were randomly divided into experimental group and control group.The experimental group was given magnesium isoglycyrrhizinate 150 mg at the beginning of the operation and postoperatively for 7 days,while the control group was not given the drug.The fasting ALT,AST,TBIL,DBIL,GGT and ALP levels were determined before operation and on days 1,3 and 7 after operation.RESULTS：Postoperative ALT and AST （except on day 3） levels in the experimental group were significantly lower than those in the control group （P〈 0.05 or 0.01）.On day 7 after operation,serum ALT levels returned to normal in 20 patients （64.5%） in the experimental group.Adverse reactions such as pseudohyperaldosteronism did not occur during the treatment course.CONCLUSION：Magnesium isoglycyrrhizinate can inhibit the rapid increase in the levels of liver enzymes,particularly serum transaminase,and reduce complications in patients after hepatectomy,and is therefore suitable for perioperative use in these patients.
出处
《世界华人消化杂志》
CAS
北大核心
2010年第2期189-194,共6页
World Chinese Journal of Digestology
关键词
异甘草酸镁
肝切除
肝功能
Magnesium isoglycyrrhizinate Liver resection Liver function
