摘要
目的:探讨乌司他丁对胆石病合并肝硬化患者外科治疗后肝功能的影响.方法:外科治疗的胆石病合并肝硬化患者97例,分为对照组和治疗组,治疗组在术后3d内静脉滴注乌司他丁.术前1d与术后1,3,5d检测肝功能,数据进行统计学分析.结果:对照组术后切口感染,难治性腹水和肺部感染的发生率分别是19.1%,12.8%和14.9%;治疗组的发生率分别是6.0%,4.0%和6.0%.对照组术后并发症发生率明显高于治疗组(P<0.05),且与肝功能Child分级有关(P<0.05).对照组术后肝功能数据明显优于对照组(P<0.05).结论:胆石病合并肝硬化围手术期应用乌司他丁能保护患者肝功能和减少并发症.
AIM： To investigate the protective effects of ulinastatin on the liver function of postoperative patients complicated with cholelithiasis and liver cirrhosis.
METHODS： Ninety-seven patients complicated with cholelithiasis and liver cirrhosis were divided into control group and therapeutic group. The patients in therapeutic group were intravenously injected with ulinastatin 3 d after operation. The liver function indexes were determined in both groups 1 d before operation and 1, 3, 5 d after operation.
RESULTS： The incidence rates of incisional wound infection, incurable ascites and pulmonary infection in the control group were 19.1%, 12.8% and 14.9%, respectively, while those in the therapeutic group were 6.0%, 4.0% and 6.0%, respectively. The rate of postoperative complication in the therapeutic group was significantly lower than that in the controls （P 〈 0.05） and correlated with Child＇s staging （P 〈 0.05）. The liver function indexes were also obviously superior to that in the controls （P 〈 0.05）.
CONCLUSION： Application of ulinastatin during peripheral operation can protect the liver function and reduce the complication rate in patients complicated with cholelithiasis and liver cirrhosis.
出处
《世界华人消化杂志》
CAS
北大核心
2006年第12期1226-1229,共4页
World Chinese Journal of Digestology
关键词
乌司他丁
胆石病
肝硬化
肝功能
Ulinastatin
Cholelithiasis
Liver cirrhosis
Liver function
