摘要
目的:探讨肝硬化肝性脑病患者血清S100B检测的临床价值。方法:收集35例正常健康体检志愿者(对照组),105例就诊我院的肝硬化患者(病例组),对所有入选者均进行血清S100B检测,另病例组均进行血氨、肝功能、电解质以及凝血功能测定,检测血清S100B采用酶联免疫法,并对观察值进行统计学处理。结果:1.肝硬化合并肝性脑病组血清S100B含量较肝硬化非肝性脑病及正常对照组明显增高,具有极显著差异(P<0.01);29例入院时已经确诊为肝性脑病的患者,经谷氨酸钠、精氨酸、甘露醇或保留灌肠等治疗后,肝性脑病病情控制,第7天复查血清S100B,较治疗前明显减低,且治疗前后比较有显著差异(P<0.05);观察15例肝性脑病合并低钠血症组血清S100B值,并与单纯肝性脑病及单纯低钠血症比较,混合组血清S100B值明显高于另外两组,有显著差异(P<0.05)。2.所有肝硬化并发肝性脑病患者经ch ild-pugh分级并与患者血清S100B值进行相关分析,发现两者高度正相关(相关系数为r=0.898)。3.对所有肝硬化患者根据血清S100B值进行分组,S100B高值组患者肝性脑病的发病率高于低值组(P<0.05);对入院时肝硬化非肝性脑病患者根据血清S100B值进行分组,S100B高值组入院后进展为肝性脑病发生率高于低值组(P<0.05)。结论:血清S100B的测定有助于肝性脑病的诊断和脑实质损害情况的判断,在临床上对病情的估计、预后的判断和及时采取有效治疗措施有一定的帮助作用。
Objective：To investigate the clinical significance of S100B in serum from patients with cirrhosis complicated by hepatic encephalopathy.Methods：The serum levels of S100B from 35 healthy contols and 105 patients wih hepatic encephalopathy were measured by enzyme-linked immunosorbent assay（ELISA）,and the liver function,electrolyte,and coagulation function determined.The data were analyzed with statistical methods.Results：1.The serum levels of S100B were markedly higher in patients with hepatic encephalopathy in those without hepatic encephalopathy,and there was a significant difference between the 2 groups（P〈0.01）.After Sodium glutamate,Arginine,Mannitolor,Retention enema therapy,the serum levels of S100B in 29 patients with hepatic encephalopathy decreased significantly along with amelioration of hepatic encephalopathy.There was a significant difference between patients who before treatment and after treatment,The serum levels of S100B in 15 patients with hepatic encephalopathy complicated with hyponatremia were markedly higher than those with hepatic encephalopathy and hyponatremia only,and there was a significant difference among those.2.After correlation study on child-pugh classification and serum levels of S100B,the correlation coefficient of child-pugh classification and S100B is very high（r=0.898）,It indicates child-pugh classification markedly positive correlated with serum levels of S100B.3.The freshpatients without hepatic encephalopathy are grouped by the serum levels of S100B,the incidence of turning into hepatic encephalopathy of the groups of higher serum levels of S100B is evidence higher than the incidence of the group of lower level.Conculsion：The serum levels of S100B are helpful to diagnose hepatic encephalopathy and estimate the severity of cerebral injury,and make for estimating the state of an illness and judging the evolving disease.
出处
《中国卫生检验杂志》
CAS
2010年第1期120-122,共3页
Chinese Journal of Health Laboratory Technology
