摘要
上皮-间质转化(EMT)是上皮细胞受到细胞外因子刺激后向间质细胞转化的现象。EMT作用于钙粘蛋白,破坏细胞间连接,并受多种生长因子与转录因子调节。在胚胎发育及肿瘤的侵袭与转移起到重要作用。
Epithelial- mesenchymal transition （EMT） refers to the specific transformation from epithelial cell to mesenchymal phenotype in response to extracellular stimulus. EMT targets to E - cadherin and destroys intercellular junction and is regulated multiple growth factors and transcription factors. EMT plays pivotal roles in embryogenesis, invasion and metastasis of malignant tumors, and other pathological processes.
出处
《现代肿瘤医学》
CAS
2010年第2期396-398,共3页
Journal of Modern Oncology
基金
国家自然科学基金(30700806)
