摘要
目的观测冠心病(CHD)患者血小板膜糖蛋白(GP)、血小板最大聚集率(PAgT)、血脂水平的变化及相关性。方法选择CHD患者122例,其中稳定性心绞痛(SAP)患者54例(SAP组),不稳定性心绞痛(UAP)患者68例(UAP组),另选健康体检者48例(对照组)。又根据有无冠状动脉事件分为心血管事件组(57例)和无心血管事件组(65例)。测定各组血GP、PAgT及血脂水平。结果 UAP组患者GP、PAgT水平明显高于对照组及SAP组患者。心血管事件组GP、PAgT也明显高于无心血管事件组;SAP组患者血小板表面α颗粒GP-140、PAgT水平明显高于对照者;回归分析发现,CHD患者PAgT水平与GP、LDL-C、脂蛋白(a)呈正相关。结论 PAgT水平升高是CHD患者冠状动脉事件发生的重要因素,高脂血症可以促进血小板在冠状动脉硬化过程中的活化。
Objective To investigate the changes of platelet glycoprotein（GP）,platelet aggregation rate（PAgT） and the blood lipid and their clinical significance in the coronary artery events in patients with CHD. Methods 122 patients with CHD were shosen as experiment group,including 54 patients with SAP group,68 patients with UAP group. Forty-eight normal persons were also chosen as control group. According to coronary artery events,the patients with CHD were divided into with coronary artery events group（57 cases） and without coronary artery events group（65 cases）. GP,PAgT and the blood lipids were measured in all groups, and the relationships of these parameters were analyzed. Results The levels of GP and PAgT in patients of UAP group were higher than those in patients of SAP group and control group,and the levels of GP and PAgT in coronary artery events group were also higher than those in without coronary artery events group. The levels of granular membrane glycoprotein 140 and PAgT in SAP group were higher than those in control group. Regression analysis showed that there were positive correlations between PAgT and GP,LDL-C,lipoprotein（a） in patients with CHD. Conclusions GP,PAgT play important roles in occurrence of coronary artery events in CHD patients. Hyperlipidemia may pro- mote the platelet activation in the coronary atherosclerosis.
出处
《中华老年心脑血管病杂志》
CAS
北大核心
2010年第1期34-36,共3页
Chinese Journal of Geriatric Heart,Brain and Vessel Diseases
基金
海南省自然科学基金(806109)
关键词
血小板膜糖蛋白类
血小板聚集
冠心病
高脂血症
血小板粘附
platelet membrane glycoproteins
platelet aggregation
coronary disease
hyperlipidemia
platelet adhesiveness
