摘要
目的研究血小板中CD62P(α颗粒的膜糖蛋白)与CD63(溶酶体的膜糖蛋白)的表达同ACS(急性冠脉综合症)之间的关系。方法 76例ACS(急性冠脉综合症)患者,随机分为A、B两组,A组急性心肌梗死患者22例,B组不稳定型的心绞痛(不稳定型心绞痛)患者54例,另选取42例正常人作为对照组C组。结果 A组CD62P的阳性表达为(6.11±1.84),B组CD62P的阳性表达为(4.18±1.51),C组CD62P的阳性表达为(2.51±0.71),A组CD63的阳性表达为(6.12±1.45),B组CD63的阳性表达为(4.22±1.26),C组CD63的阳性表达为(2.19±0.81),AB组同C组相较,差异显著(P<0.01),A组同B组相较,差异显著(P<0.01)。结论血小板中CD62P(α颗粒的膜糖蛋白)与CD63(溶酶体的膜糖蛋白)的表达,系患者冠状动脉内的血栓形成以及心肌梗死初期的影响因素,对其准确测定有助于临床诊断及预防,并且对疗效监测与预后判断都具有重要的临床价值。
Objective To explore the relationship between the expressions of CD62P （ the membrane glycoprotein alpha particles） and CD63 （lysosomal membrane glycoprotein） and the acute coronary syndrome （ACS） in platelet membranes. Methods 76 patients with ACS were randomly divided into Group A of 22 cases of acute myocardial infarction and Group B of 54 cases of unstable angina group. 42 normal subjects formed a control group （ Group C）. Results The CD62P positive expressions of Group A, Group B and Group C were （6.11 ± 1.84） % , （4.18 ± 1. 51 ）% and （2.51 ± 0.71 ）% respectively. The CD63 positive expressions of Group A, Group B and Group C were （6.12 ± 1.45）% , （4.22± 1.26）% and （2.19 ± 0.81）% respectively. Significant differences were found when Group A and Group B group were compared with group C （ P 〈0.01 ） and when Group A was compared with Group B （ P 〈 0.01 ）. Conclusion The CD62P and CD63 expressions in patients are the influencing factors of thrombopoiesis and early myocardial infarction and the determination of them can contribute to the clinical diagnosis and prevention of the disease, the monitoring of curative effects and the evaluation of the prognosis.
出处
《山东医学高等专科学校学报》
2013年第1期15-16,共2页
Journal of Shandong Medical College
