摘要
为探讨羟基磷灰石（ＨＡ）修复眶骨缺损及凹陷畸形的机制，将多孔块状羟基磷灰石植入家兔软组织及眶骨膜下，观察其组织反应，为临床应用提供进一步理论依据。临床对１４例、１７处眶骨畸形以ＨＡ进行修复，观察６～２４个月，平均１６个月，术后行Ｘ线及同位素检查。结果：动物实验证实ＨＡ无免疫反应及炎性反应，具有良好的生物相容性。临床应用１４例效果满意，术后１年以上Ｘ光片未见植入物的密度，边界及大小的改变，同位素检查证实植入半年后植入侧的血流接近正常。
Subject:To study the mechanism of repairing orbit bone defects with Hydroxyapatite(HA)and to enlarge the clinical use of HA.Method:In experiment,we implanted porous HA pieces into the rabbit muscles and under the periosteum,observed the tissues reactions,for furnishing more theroy basis for clinical use.In clinical study,we repaired 17 sites in 14 cases of orbit bone defects with HA,observed 6 to 24 months.Parts of cases were examined by x ray and radiosotope.Result:The experiment confirmed that HA had no immunity and inflammatory reactions,but had well biocompitibility.Clinical use in 14 cases got satisfactory result.After one year of implantation,the dense,border and range of implant have not any change.The radioisotope examination confirmed that the blood floow of implant site closed to the normal site after half a year.Conclusion:Porous HA is a good kind of implant in reparing orbit bone defect.
出处
《中国实用眼科杂志》
CSCD
1998年第9期553-556,共4页
Chinese Journal of Practical Ophthalmology
