摘要
目的部分抗－ＨＢｓ阳性者仍有活动性肝病存在，其病因还不十分清楚．本研究旨在探讨血清抗ＨＢｓ阳性慢性肝病患者的病因．方法应用套式聚合酶链反应检测血清抗ＨＢｓ阳性慢性肝病患者血清中ＨＢＶＤＮＡ和ＨＣＶＲＮＡ．患者３２例，男２５例，女７例，平均年龄４１７岁（２１岁～６３岁），其中慢性肝炎１８例，肝硬变１４例．９例慢性肝炎和５例肝硬变经肝活检证实，其余为临床诊断．结果血清中ＨＢＶＤＮＡ和ＨＣＶＲＮＡ的检出率分别为６２５％（２０／３２）和２８１％（９／３２）；ＨＢＶＤＮＡ和（或）ＨＣＶＲＮＡ总检出率为８１３％（２６／３２）．结论血清抗ＨＢｓ阳性慢性肝病患者的病因多数与ＨＢＶ和（或）ＨＣＶ感染有关．
IM To investigate the causes of chronic liver diseases with positive serum antiHBs. METHODS HBV DNA and HCV RNA were detected in the sera from antiHBs positive patients with chronic liver diseases using nested polymerase chain reaction. Thirtytwo patients (25 male, 7 female) with average age of 417 years (21 to 63 years) were studied, including 18 chronic hepatitis and 14 cirrhosis. Nine cases of chronic hepatitis and 5 cases of cirrhosis were diagnosed by liver biopsy and the others based on the clinical diagnostic criteria. RESULTS The positive rates of HBV DNA and HCV RNA were 625%(20/32) and 281%(9/32) respectively, with a total detectable rate of 813%(26/32). CONCLUSION Serum antiHBs positive patients with chronic liver diseases are mostly related to HBV and/or HCV infection.
关键词
病毒性肝炎
病因学
肝炎表面抗原
遗传学
おepatitis, viral, human/etiology
hepatitis B surface antigens/analysis
hepatitis B virus/genetics
hepatitis Clike viruses/genetics
DNA, viral/analysis
