摘要
目的探讨四肢骨折手术前后C反应蛋白（CRP）的变化及其临床意义。方法抽取骨折手术患者入院时、术前1 d、术后1-6 d及12 d的血标本,用散射比浊法测量CRP。结果术后无并发症的患者CRP变化相似：术后2 d出现的峰值水平与骨折部位有关,并反映手术创伤程度。深部切口感染术后4 d CRP临界值为96 mg/L。结论根据CRP反应动力学确定骨折术后时间相关的CRP参考值。CRP偏离参考值特别术后4 d〉96 mg/L,有助于早期发现术后感染并发症。
Objective To explore clinical significance of C-reactive protein（CRP） levels before and after limb fracture surgery.Methods Blood samples were obtained on admission,the first preoperative day,the days between 1 and 6 postoperatively,and on the 12th postoperative day.CRP was measured by an automated process called nephelometry.Results In the uneventful cases,a similar evolution in CRP concentrations was found： the peak level,which occurred on the second postoperative day,depended on the region and reflected the extent of surgical trauma.For deep wound infection,a cutoff level of 96 mg/L after the fourth day of surgery was recorded.Conclusions CRP kinetics permit establishment of a time-dependent set of reference values of CRP after operative fracture treatment.Deviations of this course especially CRP concentrations above 96 mg/L after the fourth day may aid in early detection of surgical complications.
出处
《临床骨科杂志》
2009年第6期618-620,共3页
Journal of Clinical Orthopaedics
关键词
C反应蛋白质
四肢骨折
外科伤口感染
C-reactive protein
limb fractures
surgerical wound infection
