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纤溶酶原激活物抑制剂1与静脉血栓栓塞性疾病 被引量：6

disease Plasminogen activator inhibitor-I and venous thromboembolic
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摘要 纤溶酶原激活物抑制剂1是纤维蛋白溶解系统的一个成分，许多研究发现血浆纤溶酶原激活物抑制剂1水平和基因多态性与静脉血栓栓塞性疾病的发生有显著的关系。 Plasminogen activator inhibitor-1 is a component in fibrinolysis system. It is reported that there is prominent relationship between plasma level, genetic polymorphism of plasminogen activator inhibitor-I and many venous thromboembolic diseases.
作者 李艳彦 翟振国 王辰
机构地区 首都医科大学附属北京朝阳医院北京呼吸疾病研究所
出处 《国际呼吸杂志》 2009年第24期1489-1492,共4页 International Journal of Respiration
基金 基金项目：国家自然科学基金资助面上项目（30770940） 北京科技新星计划（20078037）
关键词 纤溶酶原激活物抑制剂1 基因多态性 肺栓塞 Plasminogen activator inhibitor-1 Genetic polymorphism Pulmonary embolism
分类号 R543.6 [医药卫生—心血管疾病]
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参考文献21

  • 1Tsantes AE,Nikolopoulos GK,Bagos PG, et al. The effect of the plasminogen activator inhibitor-1 4G/SG polymorphism on the thrombotic risk. Thromb Res, 2008,122 : 736-742.
  • 2Henry M, Tregouet DA, Alessi MC, et al. Metabolic determinants are much more important than genetic polymorphisms in determining the PAI-1 activity and antigen plasma concentrations: a family study with part of the Stanislas Cohort. Arterioscler Thromb Vase Biol, 1998, 18 : 84-91.
  • 3Mlynarska A, Waszyrowski T, Kasprzak JD. Plasminogen activator inhibitor-1 (PAI-1) : pathogenetic role in coronary disease. Kardiol Pol, 2007,65 : 1109-1114.
  • 4Agren A, Wiman B, Schulman S. Low PAI-1 activity in relation to inflammatory parameters, insulin profile and body mass index. J Intern Med, 2008,264 : 586-592.
  • 5Dichtl W, Ares MP, Stollenwerk M, et al. In vivo stimulation of vascular plasminogen activator inhibitor-1 production by very low-density lipoprotein involves transcription factor binding to a VLDL-responsive element. Thromb Haemost, 2000,84 : 706-711.
  • 6Eriksson P, Nilsson L, Karpe F, et al. Very-low-density lipoprotein response element in the promoter region of the human plasminogen activator inhibitor-1 gene implicated in the impaired fibrinolysis of hypertriglyceridemia. Arterioscler Thromb Vase Biol, 1998,18 : 20-26.
  • 7吴春芳,陈良华,陆国平,龚兰生.脂蛋白(a)对HepG_2细胞纤溶酶原激活物抑制物-1分泌的影响[J].中华心血管病杂志,1999,27(3):231-233. 被引量：35
  • 8Usalan C, Buyukhatipoglu H. A dynamic comparative study concerning the effects of angiotensin-converting enzyme inhibitors and aldosterone receptor blockers on the fibrinolytie system. Clin Appl Thromb Hemost, 2008,14 : 203- 209.
  • 9Nielsen NE, Logander E, Swahn E. Fibrinolytic variables in postmenopausal women with unstable coronary artery disease. J Thromb Thromblysis,2001.12 : 217-223.
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二级参考文献12

  • 1Francis CW.Plasminogen activator inhibitor-1 levels and polymorphisms.Arch Pathol Lab Med,2002,126:1401-1404.
  • 2Iwai DA,Shimoike H,Nakamura Y,et al.The 4G/5G polymorphism of the plasminogen activator inhibitor gene is associated with the time course of progression to acute coronary syndromes.Atherosclerosis,1998,136:109-114.
  • 3Xiao W,Oefner PJ.Denaturing high-performance liquid chromatography:a review.Hum Mutat,2001,17:439-474.
  • 4Nilsson IM,Ljungner H,Tengborn L.Two different mechanisms in patients with venous thrombosis and defective fibrinolysis:low concentration of plasminogen activator increased concentration of plasminogen activator inhibitor.BMJ,1985,290:1453-1456.
  • 5Dawson S,Hamsten A,Wiman B,et al.Genetic variation at the plasminogen activator inhibitor-1 locus is associated with altered levels of plasminogen activator inhibitor-1 activity.Arterioscler Thromb,1991,11:183-190.
  • 6Ericksson P,Kallin B,van't Hooft FM,et al.Allele-specific increase in basal transcription of the plasminogen-activator inhibitor 1 gene is associated with myocardial infarction.Proc Natl Acad Sci USA,1995,92:1851.
  • 7Grubic N,Stegnar M,Peternel P,et al.A novel G/A and the 4G/5G polymorphism within the promoter of the plasminogen activator inhibitor-1 gene in patients with deep vein thrombosis.Thromb Res,1996,84:431-443.
  • 8Sartori MT,Wiman B,Vettore S,et al.4G/5G polymorphism of PAI-1 gene promoter and fibrinolytic capacity in patients with deep vein thrombosis.Thromb Haemost,1998,80:956-960.
  • 9Ridker PM,Hennekens CH,Lindpaintner K,et al.Arterial and venous thrombosis is not associated with the 4G/5G polymorphism in the promoter of the plasminogen activator inhibitor gene in a large cohort of US men.Circulation,1997,95:59-62.
  • 10Akar N,Yilmaz E,Akar E,et al.Effect of plasminogen activator inhibitor-1 4G/5G polymorphism in Turkish deep vein thrombotic patients with and without FV1691 G-A.Thromb Res,2000,97:227 -230.

共引文献46

同被引文献78

引证文献6

二级引证文献21

国际呼吸杂志
2009年 第24期

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