摘要
目的:探讨了再生障碍性贫血患者治疗前后血清TNF-α、VEGF和TSGF水平的变化及意义。方法:应用放射免疫分析、酶免法和化学法对33例再生障碍性贫血患者进行了血清TNF-α、VEGF和TSGF检测,并与35例正常健康人作比较。结果:再生障碍性贫血患者在治疗前血清TNF-α、TSGF水平非常显著地高于正常人组(P<0.01),而血清VEGF水平则非常显著地低于正常人组(P<0.01),血清TNF-α和TSGF水平与VEGF水平呈明显负相关(r=-0.5192、-0.6018,P<0.01),经治疗3个月后与正常人组比较仍有差异(P<0.05)。结论:检测再生障碍性贫血患者血清TNF-α、VEGF和TSGF水平的变化对了解病情、指导治疗具有重要的临床价值。
Objective To explore the clinical significance changes of serum TNF-α,VEGF and TSGF levels after treatment in patients with aplastic Anemia.Methods Serum TNF-α（with RIA）,VEGF（with ELISA） and TSGF（with biochemistry） levels were determined in 33 patients with aplastic anemia both before and after treatment and 35 controls.Results Before treatment,the serum TNF-α,TSGF levels were significantly higher in the patients than those in controls（P〈0.01）,but serum VEGF levels were significantly lower in the patients（P〈0.01）.Serum TNF-α,TSGF levels were negatively correlated with levels of VEGF（r=-0.5192,-0.6018,P〈0.01）.After a course of treatment,the serum TNF-α,VEGF and TSGF levels,though corrected markedly,remained significantly different from those in controls（P〈0.05）.Conclusion Determination of serum TNF-α,VEGF and TSGF levels after treatment might be of prognostic importance in patients with aplastic anemia.
出处
《放射免疫学杂志》
CAS
2009年第6期567-568,共2页
Journal of Radioimmanology
关键词
再生障碍性贫血
肿瘤坏死因子-Α
血管内皮生长因子
肿瘤特异性生长因子
aplastic anemia
tumor necrosis factor-α（TNF-α）
vascular endothelium growth factor（VEGF）
tumor specific growth factor（TSGF）
