摘要
多糖的生物、药物活性与其化学结构之间有非常重要的关系．许多抗肿瘤的葡聚糖都是以β－（１－３）连接为主链，具有β－（１－６）分支和三股螺旋结构的葡聚糖大分子［１，２］．多糖的生物活性除受主链的连接方式、分子大小和分支度的影响外，还与其高级结构密切相关［...
β (1 3) Glucan isolated from the cell wall of the yeast, Saccharomyces cerevisiae, is a kind of immunomodulating glucan.In order to understand the relationship between structure and function,the solubility,viscosity and the conformation in the solution of modified yeast glucan——CMGs were studied.The results indicated that the solubility and viscosity of CMGs increased with increment of substituting degree( DS ),while the solubility showed satisfied results when DS is higher than 0.2.The viscosity of CMGs was also affected by the content of protein.By using the helix coil transition analysis method,the results showed that λ max of CMG was longer than of dextran in the solutions of NaOH with different concentration.It was concluded that CMGs in the solution existed in the form of partial helix structure.
出处
《中国生物化学与分子生物学报》
CAS
CSCD
1998年第5期636-640,共5页
Chinese Journal of Biochemistry and Molecular Biology
关键词
改性酵母葡聚糖
性质
溶液
构象
Yeast glucan,Solubility,Viscosity,Helix conformation.
