急性冠脉综合征介入治疗后脑钠肽水平与心血管事件关系探讨被引量：1

Relationship between brain natriuretic peptide levels in and car diovascular eventspatients with acute coronary syndrome after percutaneous coronary intervention

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摘要目的:探讨急性冠状动脉综合征(ACS)患者行经皮冠状动脉介入治疗(PCI)术后48h血浆脑钠肽(BNP)水平变化与近、远期心血管事件关系。方法:对92例ACS患者常规进行术前和术后治疗并规范化行PCI术,术后48h行BNP测定,A组血浆BNP水平>80pg/ml,B组血浆BNP水平<80pg/ml;观察两组住院期间及术后6个月心血管事件发生率。结果:A组住院期间心血管事件发生率明显高于B组(P<0.01);但两组术后6个月心血管事件发生率无明显差异(P>0.05)。结论:ACS患者行PCI术,术后48hBNP浓度仅能预测近期预后而对远期预后无明显的预测作用。 Objective： To analyze the relationship between variation of brain natriuretic peptide （BNP）and short and long-term cardiovascular events in patients with acute coronary syndrome （ACS） at 48 hours after percutaneous coronary intervention（PCI） . Methods： Totally 92 patients with AGS were given conventional preoperative and postoperative medication and standardized PC1. Plasma levels of BNP were measured at 48 hours after operations. All patients were divided into two groups according to the level of BNP： A group （BNP 〉 80pg/ml） and B group （BNP 〈 80pg/ml）. The incidence of cardiovascular events during hospitalization and at 6 months after PCI was analyzed. Results： Compared with B group, the incidence of cardiovascular events in A group was significantly higher during hospitalization（P〈0. 01）,but there was no difference at 6 months after PCI（P〉0. 05）. Conclusion： BNP concentration in patients with ACS at 48 hours after PCI can only predict short-term prognosis, but can not predict the long-term prognosis.

作者廖伟张义效周爱琴

机构地区赣南医学院第一附属医院北京大学第一医院

出处《陕西医学杂志》 CAS 2009年第12期1630-1631,共2页 Shaanxi Medical Journal

关键词冠状动脉疾病/治疗利钠肽脑 @经皮冠状动脉介入术 Coronary syndrome Natruretic peptide brain @PCI

分类号 R544.1 [医药卫生—心血管疾病] R541.6 [医药卫生—心血管疾病]

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1Jarcho J,Friedl W,Thomas S, et al. Natriuretic peptides in assessment of left veutriculat dysfunction. Scand J Clin Lab Iab Invest, 1999,59(supple230) : 132-142.
2Hama Rs, Pearlman JD, siegel AH,et al. Detection of exercise-induced ischemin by changes in B-type natriuretic peptides. J Am Coll Cardiol, 2004,44: 1980- 1987.
3Delemos R,Stojanovic A, Mijaipovic Z,et al. Natriuretic peptides and mltinarker approach to risk stratification of patients with acute coronary syndromes. Med Pregl, 2006,59(5-6):248-52.
4王昌育,李涛,廖菽丹,辛渭川,丁辉,龚敏.急性冠脉综合征患者血浆脑钠肽检测及其意义[J].陕西医学杂志,2007,36(8):1001-1003. 被引量：2
5黄江渝,王娴,张艳.血清脑钠素水平与心衰的临床研究[J].陕西医学杂志,2007,36(8):1069-1070. 被引量：14

二级参考文献9

1郝春艳,李茹香.脑钠素对心力衰竭严重程度评估的临床研究[J].中西医结合心脑血管病杂志,2005,3(5):394-395. 被引量：15
2Butler J,Ememan,Peacock WF,et al.The efficacy and safety of B-type natriuretic peptide nesirilide in patients with renal insufficiency and acuity decompensaied congestive heart failure.Nphrol Dial Transplant,2004,19 (2):391
3Goto T,Takase H,Tortyama T,et al.Circulating concertrations of cardiac proteins indicate the severity of congestive heart failure.Heart,2003,89:1303.
4Mair J,Friedl W,Thomas S,et al.Natriuretic peptides in assessment of left veutriculat dysfunction.Scand J Clin Lab Invest,1999,59(supple 230):132-142.
5De Lemos JA,Morrow DA,Bentley JH,et al.The prognostic value of B-type natriureric peptide in patients with acute coronary syn-dromes.N Engl J Med,2001,345:1014.
6James SK,Lindahl B,Siegbahn A,et al.N-terminal pro-brain natriuretic peptide and other risk markers for the separate prediction of mortality and subsequent myocardial infarction in patients with unstable coronary artery disease:a Global Utilization of Strategies To Open occluded arteries (GUSTO)-Ⅳ substudy.Circulation,2003,108(3):275.
7Foote RS,Pearlman JD,Siegel AH,et al.Detection of exercise-induced ischemin by changes in B-type natriuretic peptides.J Am Coll Cardiol,2004,44:1980-1987.
8Matunovic R,Stojanovic A,Mijailovic Z,et al.Natriuretic peptides and mltimarker approach to risk stratification of patients with acute coronary syndromes.Med Pregl,2006,59(5-6):248-52.
9Zeller M,cottin Y,Laurent Y,et al.N-terminal pro-brain natriuretic peptide levels in patients with non-ST-elevation myocardial infarction.Cardiology,2004,102:37-40.