摘要
目的探讨基质金属蛋白酶-9（MMP-9）的表达在颅内脑膜瘤患者经手术治疗后复发和残瘤生长中的意义。方法选择因复发或残瘤生长而进行手术的脑膜瘤患者44例（71个脑膜瘤标本）做为实验组，同期非复发性脑膜瘤患者30例（30个脑膜瘤标本）做为对照组，应用Envision免疫组化法检测脑膜瘤MMP-9的表达，分析不同手术次数、切除程度和病理分级间肿瘤MMP-9表达及患者无进展生存期（RFS）的差异。结果实验组患者脑膜瘤MMP-9表达高于对照组，差异有统计学意义（P〈0．05），并且实验组中手术次数越多，患者MMP-9表达有增高趋势；与WHOI级脑膜瘤患者比较，WHOⅡ级患者MMP-9表达增高，RFS降低，差异有统计学意义（P〈0．05）。结论MMP-9的高表达可能参与脑膜瘤的复发和残瘤生长过程。
Objective To investigate the expression of matrix metalloproteinase-9 （MMP-9） and determine the biologic significance of MMP-9 in the meningioma recurrence and regrowth after surgery. Methods The expression level of MMP-9 were examined by immunohistochemistry （Envision method） in 74 patients with meningioma, including 30 with primary meningioma without recurrence （control）, and 44 with meningioma recurrence and regrowth after surgery （71 samples, experimental）. The relation between recurrence-free survival （RFS） and the expression of MMP-9 in different grades of meningioma with different operation frequency and resection degree was analyzed in these 101 samples. Results The mean expression of MMP-9 in the experimental group was significantly higher as compared with that in the control group （P〈0.05）; increased expression of MMP-9 was found following the increase of operation frequency in the experimental group; no obviously decreased expression of MMP-9 was found following the increase of recession degree in the experimental group, but the expression of MMP-9 in patients with grade II meningioma was significantly increased than that in patients with grade I meningioma and the RFS was statistically decreased （P〈0.05）. Conclusion MMP-9 may be involved in recurrence and regrowth of grade II meningioma, and increased expression of MMP-9 can be considered as an indicator for a high risk of recurrence and regrowth ofmeningioma.
出处
《中华神经医学杂志》
CAS
CSCD
北大核心
2009年第12期1248-1251,共4页
Chinese Journal of Neuromedicine
