摘要
目的探讨细胞间黏附分子-1(ICAM-1)、基质金属蛋白酶-9(MMP-9)在人脑胶质瘤的表达及相关性研究。方法采用免疫组织化学法检测82例胶质瘤组织中ICAM-1、MMP-9的表达水平。结果ICAM-1在82例人脑胶质瘤蜡块组织中全部呈阳性表达,72例MMP-9呈阳性表达,阳性率87.80%,实验对照为脑外伤手术减压的脑组织11例未见ICAM-1、MMP-9表达。ICAM-1、MMP-9阳性表达水平在胶质瘤高度恶性组高于低度恶性组,差别有显著性意义(P<0.01)。ICAM-1和MMP-9在人脑胶质瘤的表达存在相关性(r=0.436)。结论ICAM-1和MMP-9在胶质瘤存在协同作用,共同参与胶质瘤的发生、发展和恶性演变,并由此推测ICAM-1与MMP-9联合检测会更好地对脑胶质瘤的恶性生物学行为进行评价和判断。
Objective To study the expression and correlation between intercellular adhesion molecule-1 （ICAM-1） and matrix metalloproteinase-9 （MMP-9） in human glioma. Methods The expression of ICAM-1 and MMP-9 in 82 samples of glioma was detected immunohistochemically. Results The expression of ICAM-1 in all of the 82 samples was positive, and the positive rate was 100%. The expression of MMP-9 in the 72 samples of glioma was positive, and the positive rate was 87.80%. In the control group consisting of 11 samples of brain tissue of cerebral trauma after decompressive surgery, there was no ICAM-1 and MMP-9 expression. The positive level of high-grade malignant glioma is higher than that of low-grade malignant glioma （P〈0.01）. There was correlation in the expression between ICAM-1 and MMP-9 （r=0.436）. Conclusion ICAM-1 and MMP-9 may play a synergistic role in the occurrence, development and malignance in glioma. Hence, it is a better way to estimate and judge the malignant biological behavior of glioma by combined detection of ICAM-1 and MMP-9.
出处
《中华神经医学杂志》
CAS
CSCD
2005年第9期911-913,共3页
Chinese Journal of Neuromedicine
