摘要
证候动物模型在中医证候以及中药药理研究中都有着重要的意义,其发展水平的滞后已经成为中医药现代化的瓶颈。以目前的研究水平来看,病证结合的动物模型是最适合中医药研究的技术平台。病证结合动物型既要以中医理论为指导,又必须能够以科学的实验方法去证实。在研究中认为,通过流行病学调查和无监督方法,建立疾病的证候诊断标准,可以保证纳入病例的客观性。以此为标准,从多种证候模型建立方法中选择出与临床最吻合的一种。再通过方证相应("证实")及方证相左("证伪")对动物模型的疗效反证,评价其可靠性。这是病证结合动物模型的建立的新思路与新方法,并为提高临床疗效及疾病实验研究提供依据。
Zheng hou animal model has the important value to traditional Chinese medicine （TCM）. However, its backward in development is a chock point of modernization of TCM. At present, disease and zheng hou animal model is the most suitable technological platform to TCM. We think that by the methods of epidemiology and unsupervised analysis, we can set up zheng hou diagnosis standard which will ensure objectivity of clinical cases. According to this standard, we will select one animal model which most closely meet clinic reality and estimate it by agreement and disagreement of prescription and zheng hou（ verify and falsify）. This disease and zheng hou animal model are not only under the leading of TCM theory, but also can be verified by experimental methods. It will be basis of clinical effectiveness and experimental research of TCM.
出处
《中华中医药学刊》
CAS
2009年第12期2525-2527,共3页
Chinese Archives of Traditional Chinese Medicine
基金
国家重点基础研究发展计划(973计划)资助项目(2003CB517101)
关键词
证候动物模型
病证结合模型
研究意义
建立方法
zheng hou animal model
disease and zheng hou animal model
research value
establishing method
