摘要
长期或反复处于缺氧状态,可以影响机体组织器官的正常供氧,使心血管、呼吸和神经等系统功能紊乱,从而诱导机体多系统损伤,严重危害人体健康。随着现代人生活方式以及饮食结构的改变,生活中有氧运动不足再加上地球污染与破坏逐年加剧,人类不知不觉地处在一个慢性缺氧的环境中。因此,了解并重视慢性缺氧对生理功能的影响造成的危害,从而采取相应的防治措施具有重要的意义。国内外学者根据宏观指征与生理生化指标等微观指征变化的不同,采用不同缺氧周期与缺氧强度制备模拟不同疾病与证候的慢性缺氧模型,对慢性缺氧诱导的生理病理演变过程进行了大量的探索研究。本文综述了近5年来慢性缺氧模型与阻塞性睡眠呼吸暂停综合征、肺动脉高压、心血管疾病、神经退行性病变等疾病以及气阴两虚、气滞血瘀等证候相关性的研究进展,为遴选体现与缺氧相关病证临床特点的动物模型,并用以合理评价药物的作用特点提供参考。
Prolonged or repeated hypoxia can affect the normal oxygen supply for tissues and organs and normal physiological function of the cardiovascular, respiratory and nervous systems. Multi-system injuries bring serious harm to human health. Along with the modem life style and dietary structure change, deficiency of aerobic exercise and the worsening earth pollution and destruction make human in a chronic hypoxic environment imperceptibly. Therefore, it is of importance ＂to pay more attention to the harm of chronic hypoxia and take corresponding prevention measures. Scholars at home and abroad largely explored constructing animal models to simulate different diseases and syndromes through observing macro and micro indications, including performance and physiological or biochemical indexes. And different oxygen cycles and different hypoxia intensities were used. Various animal models of chronic hypoxia have been commonly used to investigate the various physiological or pathological processes of hypoxia-related diseases including obstructive sleep apnea syndrome, pulmonary artery hypertension, cardiovascular diseases, neurodegenerative disease and Deficiency of both Qi and Yin syndrome, Stagnation of Qi and blood stasis. In this paper, the recent studies on relationship of chronic hypoxia model and the related diseases and syndromes were reviewed. It is inclined to provide some clues not only for selecting reasonable animal models simulating the clinical features of diseases and syndrome but also for evaluating the characters of drug action reasonably.
出处
《现代生物医学进展》
CAS
2012年第33期6572-6577,6557,共7页
Progress in Modern Biomedicine
基金
"十一五"国家科技支撑计划(2008BAI151B03)
中央高校科研专项基金(JKP2011011)
关键词
慢性缺氧
动物模型
疾病
证候
Chronic hypoxia
Animal model
Diseases
Syndromes
