摘要
目的研究神经节苷酯对老年性学习记忆减退鼠空间学习记忆的影响。方法用Ｍｏｒｉｓ水迷宫筛选老年性学习记忆减退昆明小鼠，腹腔注射神经节苷酯１４天，然后测试小鼠定位航行和空间探索能力。结果与老年学习记忆减退鼠对照组比较，治疗组平均逃避潜伏期缩短，原平台游泳距离和穿环数次却增大，但均未达到老年学习记忆正常组和青年组水平。结论提示神经节苷酯可改善老年性学习记忆减退鼠空间学习记忆能力。
Objective To study the effect of ganglioside on spatial learning and memory in learning and memory deficit mouse. Methods Learning and memory deficit mice were selected from aged mice by using Morris water maze and received daily injection of ganglioside for 14 days, then analyzed the parameter of place navigation test and spatial probe test by Morris water maze test. Result The aged learning and memory deficit drug treated group (drug treat group) had significantly shortened in escape latency compared with aged learning and memory deficit control group (control group). The drug treat group had significantly increased compared with control group in both of the percentage of swim distance in platform quadrant and the number of crossing platform, but the parameter of drug treat group still not reached the levels of parameter of both young group and aged normal learning and memory group. Conclusion It is showed ganglioside improved spatial learning and memory in learning and memory deficits aged mouse.
出处
《中国行为医学科学》
CSCD
1998年第3期179-181,共3页
Chinese Journal of Behavioral Medical Science
