摘要
目的:探讨Livin和张力蛋白同源10q丢失的磷酸酶基因(phosphatase and tensin hornology deleted on chromosome 10,PTEN)的表达与卵巢上皮性癌的临床病理学特征的关系及其相关性。方法:采用免疫组织化学EliVision法检测60例卵巢上皮性癌组织、20例良性卵巢上皮性肿瘤及20例正常卵巢组织中Livin及PTEN表达情况。结果:卵巢上皮性癌中Livin阳性率(80.0%)均明显高于卵巢良性上皮性肿瘤(10.0%)及正常卵巢组织(5.0%)(P<0.01)。卵巢上皮性癌的组织病理学分级间Livin的阳性率差异有统计学意义(P<0.01),而在临床分期及淋巴结转移中差异均无统计学意义(P>0.05)。卵巢上皮性癌中PTEN的阳性率(26.7%)均明显低于卵巢良性上皮性肿瘤(95.0%)及正常卵巢组织(100.0%)(P<0.01);卵巢上皮性癌的临床分期、组织病理学分级及淋巴结有无转移间PTEN的阳性率差异均有统计学意义(P<0.01)。卵巢上皮性癌中Livin的阳性率与PTEN的阳性率呈负相关关系(P<0.01)。结论:Livin的表达上调及PTEN的表达下调在卵巢上皮性癌的发生、分化进展中起重要作用,Livin基因有可能成为治疗卵巢癌的新靶点。
Objective：To study the expression and pathological characteristics of Livin and PTEN proteins in epithelial ovarian carcinoma as well as their inter-relationship. Methods：The Expression of Livin and PTEN in 60 samples of ovarian epithelial carcinoma,20 samples of benign ovarian epithelial tumor and 20 normal ovarian tissues were detected by immunohistochemistry. Results：The Livin protein expression（80.0%） in epithelial ovarian carcinoma tissues was significantly higher than that of benign ovarian epithelial tumors（10.0%） and normal ovarian tissues（5.0%）（P〈0.01）.The expression of Livin had a positive correlation with the tumor grade,but no statistical correlation with the tumor stage or lymph node metastasis.The positive expression of PTEN protein in epithelial ovarian carcinoma（26.7%） was significantly lower than that in benign ovarian epithelial tumors（95.0%） and normal ovarian tissues（100.0）（P〈0.01）.The expression of PTEN was negatively related to the tumor stage,tumor grade and lymph node metastasis（P〈0.01）;the expression of Livin was negatively correlated with the expression of PTEN（P〈0.01）. Conclusions：Up-regulated expression of Livin and down-regulated expression of PTEN may play an important role in the process of carcinogenesis and differentiation of epithelial ovarian carcinoma.Livin may be useful targets for treatment of ovarian carcinoma.
出处
《蚌埠医学院学报》
CAS
2011年第3期223-226,共4页
Journal of Bengbu Medical College
关键词
卵巢肿瘤
凋亡抑制基因
表达
病理学
相关性
ovarian neoplasmas
apoptosis inhibitor gene
expression
pathological
correlation
