摘要
勃起功能障碍(ED)的发生与血管内皮功能障碍及相关神经的损伤有关。近年来,干细胞对阴茎勃起神经和海绵体血管内皮细胞修复保护作用的临床前研究已成为研究的热点。早期研究显示干细胞或基因修饰的干细胞对ED治疗持久有效,并有可能成功治愈ED。间充质干细胞、肌源性干细胞、胚胎干细胞、脂肪源性干细胞、内皮祖细胞等均具有不同的分化潜能,在内皮细胞的更新、修复及神经组织细胞的保护方面有各自的优势。干细胞有望用于人类ED的治疗。
Erectile dysfunction（ED） commonly results from endothelial dysfunction and erectile nerve damage.Recent researches have focused on the preclinical studies of stem cell-based therapies targeted at repairing penile endothelium and protecting erectile nerves.Early studies showed that stem cell-or gene-modified stem cell-based therapies may have enduring efficacy and eventually lead to a cure for ED.Such stem cells as embryonic,mesenchymal,muscle-derived and adipose-derived ones and endothelial progenitor cells all have differentiation potentials and obvious advantages in protecting and repairing both nervi erigentes and corpus cavernosum vascular endothelial cells.Stem cell-based therapies promise to be an effective approach to human erectile dysfunction.
出处
《中华男科学杂志》
CAS
CSCD
北大核心
2009年第10期937-940,共4页
National Journal of Andrology
关键词
间充质干细胞
肌源性干细胞
胚胎干细胞
脂肪源性干细胞
内皮祖细胞
勃起功能障碍
mesenchymal stem cell
muscle-derived stem cell
embryonic stem cell
adipose-derived stem cell
endothelial progenitor cell
erectile dysfunction
