摘要
目的研究不同粒度续断饮片中有效成分续断皂苷Ⅵ溶出速率及雌激素样作用。方法采用高效液相色谱法分别测定续断粗粉、细粉和超微粉中续断皂苷Ⅵ的含量和溶出速率;采用小鼠子宫增重法测定子宫系数,研究不同粒度续断饮片的雌激素样作用。结果续断超微粉饮片中续断皂苷Ⅵ溶出速度较快,且雌激素作用较强。结论续断超微粉饮片疗效好,优于续断粗粉饮片和细粉饮片。
Objective To study the dissolution property and estrogenic effects of asperosaponin Ⅵ from Radix Dipsaci with different sizes of particle. Methods The contents, dissolution quantity and rate of asperosaponin VI were determined by HPLC. The estrogenic actions of asperosaponin Ⅵ with coarse, fine and superfine powders were studied on mice. Results The superfine powder had a good dissolution rate and strong estrogenic effects. Conclusion The superfine powder is better than the others on estrogenic effects.
出处
《医药导报》
CAS
2009年第11期1402-1404,共3页
Herald of Medicine
基金
国家自然科学基金重点资助项目(基金编号:30730113)
关键词
川续断
溶出速率
子宫系数
Radix Dipsaci
Dissolution rate
Uterus coefficient
