摘要
用188W／188Re发生器淋洗液制备了骨肿瘤治疗剂188Re－HEDP。188Re－HEDP的最佳标记条件为：5mgHEDP，2.0mgSnCl2和1mgVc。在pH2．0的条件下，标记率大于95％，其体外12h内稳定性良好。在制备188Re－HEDP时加入辅剂，注射后4h，小鼠股骨摄取为（7.86±1．62）％ID／g；而对照组仅有（1．92±0.61）％ID／g（P＜0.01）。兔全身显像清晰，说明188Re－HEDP是一个很有前途的骨肿瘤治疗剂。
188Re-HEDP have been prepared with 188Re eluted from a 188W/188Re generator.The best labelling condition is 5 mg HEDP, 2.0mg SnCl2, and 1 mg Vitamin C, PH2.0.Labelling yield is greater than 95%. The in vitro stability of 188Re-HEDP is good in 12 hours. By adding some adjunct reagent in preparation, femur uptake raised to 7.86 ±1.62%/g after 4 hours. As compared with control uptake 1.92±0.61%/g in mice (P<0.01). Clear whole body images of rabbit has been obtained. Thereby 188Re-HEDP is a good potential candidate for the treatment of bone tumor.
出处
《核技术》
CAS
CSCD
北大核心
1998年第11期697-700,共4页
Nuclear Techniques
