摘要
目的:比较甘氨双唑钠(CMNa)与顺铂(DDP)在食管癌放射治疗(RT)中的增敏作用和副作用。方法:食管癌首程放疗患者95例被随机分为CMNa+RT、DDP+RT及RT组。用药方法:CMNa+RT组:800mg/m2生理盐水100ml静滴,30min内输完,1h内行放疗。每周一、三、五,至放疗(照射剂量:65～74Gy)结束。DDP+RT组:10mg+生理盐水250ml静滴,每周一、四,至放疗结束。结果:CMNa+RT组和DDP+RT组的完全缓解率较RT组明显升高(P<0.05),CMNa和DDP增敏作用比较差异无统计学意义(P>0.05)。CMNa组的毒副反应发生率明显低于DDP组。结论:CMNa和DDP对食管癌均具有放疗增敏作用,两者无明显差异,而CMNa组副作用少,其远期疗效有待进一步研究。
Objective：To compare radiosensitivity enhancement between DDP（Cisplatin） and CMNa（Sodium Glycididazole） in patients with intermediate and advanced esophageal carcinoma.Methods：95 patients with esophageal carcinoma were randomized into three groups.There were 33 cases in RT（Radiation Treatment） group.There were 30 cases in CMNa ＋RT group,administrated with CMNa 800 mg/m2,every Monday,Wesday,and Friday.The regimen was repeated every week till the end of the radiotherapy（DT：65～74 Gy）.There were 32 cases in DDP＋ RT group,administrated with DDP 10mg,d1.4.The regimen was repeated every week till the end of the radiotherapy.Results：CMNa and DDP could enhance the radiosensitivity to advanced esophageal carcinoma.The radiosensitivity enhancement of two groups were similar（P〉0.05）.The side-effect in DDP group was more severe than in CMNa ＋ RT group.Conclusion：There is no significant difference in radiosensitivity in two groups,but CMNa ＋ RT regimen was more tolerable than DDP＋ RT regimen.The long term effect needs further study.
出处
《重庆医科大学学报》
CAS
CSCD
北大核心
2009年第8期1108-1111,共4页
Journal of Chongqing Medical University
