摘要
目的探讨周剂量紫杉醇对局部晚期食管癌的放疗增敏作用。方法将44例不宜手术的局部晚期食管癌患者随机分为放疗增敏组和单纯放疗组,每组22例。2组放疗方法相同,均采用常规设野,常规分割外照射,总剂量60～66 Gy。放疗增敏组在放疗同期每周接受1次紫杉醇(40 mg.m-2)化疗,连用6周。结果 44例患者均可评价疗效,放疗增敏组与单纯放疗组有效率分别为86.4%和63.6%(P<0.05);1 a局部控制率分别为77.3%和50.0%(P<0.05);1 a无复发生存率分别为72.7%和45.5%(P<0.05);1 a生存率分别为81.8%和54.5%(P<0.05)。2组毒副反应相似,患者均可耐受。结论周剂量紫杉醇对局部晚期食管癌放疗具有明显的增敏作用,能提高患者的局部控制率和生存率,且毒副反应未明显增加。
Objective To evaluate the radiosensitizing effect of weekly-dose paclitaxel on locally advanced e- sophageal carcinoma. Methods Forty-four patients with unresectable locally advanced esophageal carcinoma were randomized into the radiosensitization group （22 patients） and the simple radiotherapy group （22 patients）. All the patients were given with the same radiotherapy （ routine fractionation radiotherapy, DT 60-66 Gy）. The 22 patients in the radiosensitization group were treated with radiotherapy combined with weekly-dose paclitaxel 40 mg · m-2 for 6 weeks, the 22 patients in the simple radiotherapy group were treated with radiotherapy alone. Results All the 44 patients could be evaluated, the response rates were 86.4% and 63.6% of the radiosensitization group and the sim- ple radiotherapy group （ P 〈 0.05 ） ; the 1 -year local control rates were 77.3% and 50.0% （ P 〈 0.05 ） ; the 1 -year failure-free survival rates were 72.7% and 45.5% （ P 〈 0.05） ; the 1-year survival rates were 81.8% and 54.5% （ P 〈 0.05 ）. The toxicities of the radiosensitization group were similar to those of the simple radiotherapy group, and were tolerated. Conclusion Weekly-dose paclitaxel potently enhances the effect of radiotherapy in the treatment of locally advanced esophageal carcinoma, and can significantly improve the local control rate and the survival rate, and don＇t increase toxicities.
出处
《肿瘤基础与临床》
2012年第6期489-492,共4页
journal of basic and clinical oncology
关键词
周剂量
紫杉醇
食管癌
放疗
同步放化疗
weekly-dose
paclitaxel
esophageal carcinoma
radiotherapy
concurrent chemoradiotherapy
