摘要
目的:探讨太行山区林州市及其周边食管癌高发区食管癌患者近年来临床病理特点的变化及遗传易感性.方法:2006-10/2008-12于安阳市肿瘤医院和林州市中心医院住院治疗的食管癌患者1259例,来自林州市及其周边食管癌高发地区,诊断年龄为33-84岁,所有患者均为首次住院和首次经内镜检查诊断并经组织学检查确诊病例.回顾分析食管癌患者的肿瘤家族史、食管癌诊断年龄、肿瘤发生部位、临床病理类型、组织学类型及分化程度、TNM分期等内容.结果:食管癌患者的诊断年龄服从正态分布,平均诊断年龄为59.82±8.17岁;家族中具有2个或2个以上食管癌或贲门癌的患者占32.0%(403/1259);家族中具有2个或2个以上成员患(包括患者本人)恶性肿瘤的患者占38.6%(486/1259),父母均患食管癌或贲门癌、胃癌者占3.9%(49/1259),家族中累及2代且至少有3个成员患食管癌或其他恶性肿瘤的患者占8.01%(102/1259),家族中累及2代且至少有3个成员(包括患者本人)患食管癌患者占6.0%(76/1259);食管癌最常发生的部位是中段,其次为上段、下段,发生部位与患者的诊断年龄密切相关(P<0.001),≤40岁、-60岁和-70岁等组的患者以中段与上段多见;中晚期食管癌患者多见,爱人或父母未患恶性肿瘤的患者中晚期较多(P<0.05);鳞癌占96.2%(1202/1250).结论:恶性肿瘤尤其是食管癌遗传易感性可能是目前林州市及其周边食管癌高发区食管癌高发的主要原因;食管癌最常发生的部位是食管中段,其次为上段;食管癌的发生部位与患者的发病年龄密切相关.
AIM： To investigate the pathological features and hereditary susceptibility of 1259 patients with esophageal cancer in a high incidence area around Taihang mountain in China. METHODS： A total of 1259 esophageal cancer patients who came from Linzhou and the surrounding area and were hospitalized at Linzhou Central Hospital and Anyang Tumor Hospital were investigated retrospectively. All patients were endoscopically and histologically diagnosed as esophageal cancer at first hospitalization. The family history of malignant tumors, age at diagnosis, tumor site, clinicopathological type, histological type, differentiation degree and TNM stage were investigated retrospectively. RESULTS： The age at diagnosis in these patients obeyed the normal distribution. The mean age at diagnosis was 59.82 ± 8.17 years. Of all esophageal cancer patients included, 32.0% （403/1259） had two or more family members with esophageal cancer or gastric cardiac cancer, 38.6% （486/1259） had two or more family members with malignant tumors, 3.9% （49/1259） had two parents with esophageal cancer, gastric cardiac cancer or gastric cancer; 8.01% （102/1259） had at least three relatives with esophageal cancer or other malignant tumors in two successive generations, 6.0% （76/1259） had at least three relatives with esophageal cancer in two successive generations. The middle part of the esophagus was most frequently affected, followed by the upper and lower parts of the esophagus. Tumor site was signif icantly correlated with the age at diagnosis （P〈0.001）. Esophageal cancer at the middle and upper esophagus often occurred in the groups of patients having an age at diagnosis ≤40, 50-60 and 60-70 years. The majority of patients suffered from middleor late-stage esophageal cancer, especially those whose parents or spouse had malignant tumors （P〈0.05）. Esophageal squamous cell carcinoma was diagnosed in 96% （1202/1250） of patients. CONCLUSION： Hereditary susceptibility to malignant tumors （mainly esophageal cancer） is currently the main cause for high incidence of esophageal cancer in Linzhou and the surrounding area. The middle part of the esophagus is most frequently affected, followed by the upper part of the esophagus. Tumor site is signif icantly correlated with the age at diagnosis in esophageal cancer patients.
出处
《世界华人消化杂志》
CAS
北大核心
2009年第23期2367-2373,共7页
World Chinese Journal of Digestology
关键词
食管癌
遗传易感性
病理学
临床
Esophageal cancer Hereditary susceptibility Pathology Clinical
