摘要
2型糖尿病患者易罹患结直肠癌,若接受胰岛素治疗,则不仅结直肠癌发病率更高,且肿瘤进展更加迅速。高胰岛素血症假说认为,异常增高的胰岛素及游离胰岛素样生长因子-1水平可促进结肠细胞增殖,最终导致结直肠癌的发生。由于结直肠癌可通过筛选试验得以早期发现,故建议2型糖尿病患者均应选择合适的筛选形式,特别是接受胰岛素治疗的患者应建议进行结肠镜检查,并且筛选间隔时间不得超过5年。
Colorectal cancer occurs more frequently in patients with Type 2 diabetes mellitus. If patients are treated with insulin, the rate of colorectal cancer would be higher, and the tumor progression would be even more rapid. The hyperinsulinemia-hypothesis suggests that the elevated levels of insulin and free IGF-1 could promote the proliferation of colon ceils, and ultimately result in colorectal cancer.Because colorectal cancer can litus should be recommended be early detected by screening tests, all patients with Type 2 diabetes melto choose appropriate screening modality. In particular, the patients, who are under insulin treatment, should routinely undergo colonoscopy and the screening intervals should not exceed 5 years.
出处
《国际病理科学与临床杂志》
CAS
2009年第5期421-425,共5页
Journal of International Pathology and Clinical Medicine
基金
湖南省自然科学基金(06JJ50047)
湖南省卫生厅课题(B2005-298)~~
关键词
2型糖尿病
胰岛素
胰岛素样生长因子-1
结直肠癌
结肠镜
筛选
Type 2 diabetes mellitus
insulin
insulin-like growth factor-1
colorectal cancer
colonoscopy
screening
