摘要
目的探讨成纤维细胞激活蛋白α（FAPα）在结肠腺癌中的表达及其临床意义。方法采用SP免疫组织化学法检结肠腺癌组织中FAPα的表达，并分析其与临床病理特征之间的关系。结果FAPα在结肠腺癌间质的成纤维细胞中表达，而在肿瘤细胞中无表达。69例结肠腺患者FAPα表达阳性率为71．0％，FAPα的表达与性别、年龄无关（P〉0．05），但与结肠腺癌的分期、分化程度和侵袭程度密切相关（P〈0．01）。提示FAPα的表达与结肠腺癌的恶性表型有关，即随着结肠腺癌恶性程度的增强，FAPα表达有不同程度的增多。结论FAPα的高表达与结肠腺癌恶性表型有关，可作为反映结肠腺癌的生物学行为指标之一。
Objective To investigate the expression of FAPα in colon adenocarcinomas and its clinical significance. Methods Expression of FAPα was detected by immunohistochemical method in the stroma of colon adenocareinoma and colon adenoma, and the relationship between expression of FAPα and clinicopathologic factors was analyzed. Results Expression of FAPα has been described to be present predominantly in the tumor stromal fibroblasts of colon adenocarcinomas, but expression of FAPα is not detected in fibroblasts of benign epithelial tumors or normal adult tissues. Expression of FAPα was positive in 49of 69 patients （ 71.0% ） with colon adenocarcinomas. Expression of FAPα was correlated with clinic stage, tumor cell differential degree and tumor infiltration depth（ P 〈 0.01 ）, but not correlatedwith sex and age（ P 〉 0.05 ）. It has been suggested that expression of FAPα maybe related to the malignant phenotype and invasion of colon adenocarcinomas. With the malignant degree of the tumor increased, the expression of FAPα increased. Conclusion Expression of FAPα maybe related to the malignant phenotype and invasion of colon cancer, and can reflect the biological behaviors of colon adenocarcinomas.
出处
《临床内科杂志》
CAS
2009年第9期606-608,共3页
Journal of Clinical Internal Medicine
关键词
结肠腺癌
成纤维细胞激活蛋白α
免疫组织化学
Colon adenocarcinomas
Fibroblast activation protein α
Lmmunohistoehemistry
