摘要
目的探讨成纤维细胞激活蛋白(Fibroblast activation protein,FAP)在胃癌组织中的表达及意义。方法应用免疫组织化学方法检测58例胃癌组织中FAP的表达,分析其与胃癌恶性生物学行为之间的关系。结果在58例胃癌组织中FAP表达阳性率为79.3%,其在正常胃组织中无表达。FAP表达与胃癌组织的分化程度、分期和分型有关(P<0.01或P<0.05),而与淋巴结转移无关。提示FAP的表达与胃癌恶性表型有关,即随着胃癌恶性程度的增强FAP表达有不同程度的增多。结论FAP的高表达与胃癌恶性表型有关,可作为反映胃癌恶性生物学行为的指标之一。
Objecfive To investigate the significance of expression of FAP in gastric carcinoma（GC）. Methods The expression of FAP in GC （58 eases） were examined by immtmohistochemieal staining, and the evaluation of relationship of FAP expression with malignant biological behaviors in gastric carcinoma also was made. Results Forty - six cases of 58（79.3% ） cancer specimens were positive for FAP, non- cancerous tissue was negative. FAP had negative. FAP had a positive correlation with the differentiation, depth of invasion and growth pattern of GC （ P 〈 0.01 or P 〈 0. 05）. but its relation to the lymph node metastasis were not significant. With the malignant degree of the tumor increased, the expression of FAP increased. Conclusion FAP expression may be related to the malignant phenotype and invasion of GC, and can reflect the biological behaviors of GC at the same time.
出处
《黑龙江医学》
2008年第1期21-23,共3页
Heilongjiang Medical Journal
