摘要
目的研究各类结核病患者的细胞免疫功能表达。方法用生物素—链霉亲和素方法检测９６例肺结核、结核性胸膜炎、肾结核患者Ｔ细胞亚群ＣＤ３＋、ＣＤ４＋、ＣＤ８＋、ｍＩＬ－２Ｒ（膜白细胞介素－２受体）水平；另选取２６例正常人群为对照组。结果结核病患者与正常人相比，ＣＤ８＋明显升高，而ＣＤ３＋、ＣＤ４＋／ＣＤ８＋及ｍＩＬ－２Ｒ均显著降低（Ｐ＜０．０１），其中肺结核患者最为明显，有空洞者较无空洞者更明显（Ｐ＜０．０１）。无空洞型肺结核与结核性胸膜炎、肾结核的Ｔ细胞亚群、ｍＩＬ－２Ｒ表达水平相似，相互间差异无显著性（Ｐ＞０．０５）。结论结核病患者体内存在明显细胞免疫功能低下，病变部位、程度及预后与ＣＤ３＋、ＣＤ４＋、ＣＤ８＋、ｍＩＬ－２Ｒ水平有一定关系。
Objective To study the expression of cellular immunity function in patients with tuberculosis. Methods The expression of T lymphocyte subpopulation CD3+,CD4+,CD8+, and membrance interleukin2 receptor(mIL2R) were detected by biotinsstreptavidin system in 96 patients with pulmonary, exudative, and kidney tuberculosis. Results The level of CD8+ was higher, and the expression of CD3+, CD4+, CD8+, CD4+/CD8+, mIL2R rate were lower in tuberculosis than those in normal controls (P<001). The change of indication in pulmonary tuberculosis was the most obvious among them (P<001). The change of exudative kidney tuberculosis was similar, and there was no significant differcene (P>005). The change of patients with cavitation was more obvious than those without it. (P<001) Conclusion The function of cellular immunity was far lower obviously in tuberculosis than in normal controls. The situation, degree and prognosis of tuberculosis were related to the level of CD3+, CD4+, CD8+, CD4+/CD8+ and expression of mIL2R.
出处
《安徽医科大学学报》
CAS
1998年第4期272-274,共3页
Acta Universitatis Medicinalis Anhui
