摘要
目的:探索活血化瘀复方治疗银屑病的可能机制。方法:建立小鼠银屑病模型和慢性血瘀模型,比较两种活血化瘀中药复方与生理盐水、甲氨蝶呤(MTX)对小鼠阴道上皮增殖、鼠尾表皮细胞分化、血浆内皮素-1(ET-1)及耳廓微循环的影响。结果:两种活血化瘀复方均对小鼠阴道上皮有丝分裂、鼠尾鳞片表皮分化、ET-1水平及小鼠耳廓微循环具有明显的调节作用。结论:活血化瘀药物可能通过阻断多个发病环节起到治疗银屑病的作用。在浓度相同的情况下,对各靶点的作用与成分有关。
Objective： To investigate the possible therapeutic mechanism of treating psoriasis with the promoting blood circulation formula. Methods： The psoriasis model and chronic disturbance of blood circulation model of mice were established. The effects of promoting blood circulation formula, Methotrcxate （MTX） and normal saline （NS） on the mitosis of mice vaginal epithelium, the granular layer formation of mice tail scale epidermis, the plasma endothelin-1 （ET-1） levels and auricle microcirculation of mice were observed and compared. Results： Two kinds of promoting blood circulation formula showed significant regulating effects on proliferation and differentiation of epidermis, ET-1 and auricle microcirculation of mice. Conclusion： The therapeutic effects of the promoting blood circulation formula on psoriasis may be achieved by blocking several links of chain in the pathogcnesis of psoriasis, and these effects are related to the components of formula under the condition of same concentration.
出处
《中国医药导报》
CAS
2009年第26期9-11,共3页
China Medical Herald
基金
广西壮族自治区研究生创新计划项目(2007106001006M16)
关键词
银屑病
血瘀
血浆内皮素-1
耳廓微循环
Psoriasis
Disturbance of blood circulation
Endothelin-1
Auricle microcirculation
