摘要
在pH4．04的HAc-NaAc缓冲液中，刚果红与盐酸氯丙嗪在室温下迅速结合生成缔合物，且缔合物在480nm处有最大吸收。基于此建立了流动注射光度法测定药物中盐酸氯丙嗪的含量。方法线性范围为0．25～50．0ug／mL，检出限为0．082ug/mL，测定频率达80次／h。
In the HAc-NaAc buffer medium （pH 4.04）, congo red （CR） bound rapidly with chlorpromazine hydrochloride at room temperature to form a complex, which showed maximum absorption at 480 nm. Based on this, the flow injection spectrophotometric method was established to determine chlorpromazine hydrochloride. Linearity was kept in the range of 0.25 - 50.0ug/mL with a detection limit of 0.082 ug/mL. The determining frequency was 80 times/h. The proposed method was applied to determining chlorpromazine hydrochloride in pharmaceuticals. The results were compared with those obtained by pharmacopoeia method with satisfaction.
出处
《分析试验室》
CAS
CSCD
北大核心
2009年第9期113-115,共3页
Chinese Journal of Analysis Laboratory
关键词
流动注射分析
盐酸氯丙嗪
刚果红
Flow injection analysis
Chlorpromazine hydrochloride
Congo red
