摘要
目的研究颈内动脉系统和椎-基底动脉系统短暂性脑缺血发作(TIA)患者在临床症状消失后的记忆功能障碍的特点及其与TIA的病程、次数及持续时间与记忆障碍的相关性。方法对42例颈内动脉系统和36例椎-基底动脉系统TIA患者在TIA末次发作后3～7d进行临床记忆量表(甲套)、简易精神状态检查量表(MMSE)、Zung抑郁自评量表测试,并与30名健康对照者进行比较;同时对TIA发作的病程、次数、持续时间与记忆障碍进行相关性分析。结果(1)颈内动脉系统组和椎-基底动脉系统组在临床记忆量表中除无意义图形再认外,其余各项的等值量表分均比正常对照组明显下降(均P<0.01),两组在临床记忆量表中的各项等值量表分比较差异无统计学意义。(2)颈内动脉系统组的即刻记忆、语言能力及MMSE总评分,椎-基底动脉系统组地点定向力、注意力和计算力及MMSE总评分均低于正常对照组(均P<0.05)。(3)颈内动脉系统和椎-基底动脉系统TIA患者的病程、发作次数、发作持续时间与临床记忆量表和MMSE的各项等值量表分之间无相关性。结论(1)颈内动脉系统和椎-基底动脉系统TIA患者在症状消失后可遗留不同程度的短时记忆障碍。(2)颈内动脉系统TIA患者可出现语言能力障碍,椎-基底动脉系统TIA患者存在地点定向力、注意力和计算力障碍。(3)颈内动脉系统和椎-基底动脉系统TIA患者的病程、发作次数、发作持续时间与记忆障碍和语言障碍无明显的相关性。
Objective To study of characters of memory disfunction of the patients with transient ischemic attack （TIA） in internal carotid artery system （ICAs） and vertebra-basilar artery system （VBAs） when the clinical symptoms disappeared, and to explore correlation between memory disability and illness course, frequency and persistence time of TIA. Methods 42 patients with TIA in ICAs（ ICAs group） ,36 patients with TIA in VBAs（ VBAs group） were measured by clinical remembrance scale, MMSE and Zung self-rating depressive scale in 3 ~ 7 d after the final attack, the results were compared with 30 health volunteers（ normal control group）. Correlation analysis was made between memory disability and illness course, frequency and persistence time of TIA. Results （ 1 ）There was no significant difference in clinical remembrance scale scores between ICAs group and VBAs group. The equivalent scale scores of clinical remembrance but insignificant figure recognition item in both TIA groups were significantly lower than that in the normal control group （all P 〈 0. 01 ）. （2）Compared with the normal control group, immediate memery,language ability and MMSE total score in ICAs group were significantly lower, and place orientation, attention ,calculation and MMSE total scale score in VBAs group were also significantly lower（ all P 〈 0.05 ）. （ 3 ） There was no significant correlation between illness course, attack frequency and attack persistence time and equivalent scale scores in clinical remembrance scale and MMSE scale in both TIA groups. Conclusions （ 1 ） Shorttime memory deficits in some degree does exist in patients with ICAs and VBAs TIA when the clinical symptom disppeared. （2） Language ability is impaired in patients with ICAs. Place orientation, attention and calculation ability is impaired in patients with VBAs. （3）There is no significant correlation between illness course, attack frequency and attack persistence time and memory or language impairment in patients with ICAs and VBAs.
出处
《临床神经病学杂志》
CAS
北大核心
2009年第4期244-247,共4页
Journal of Clinical Neurology
基金
开封市科技攻关计划项目(060339)
关键词
短暂性脑缺血发作
颈内动脉
椎-基底动脉
记忆
神经心理学
transient ischemie attack
internal carotid artery
vertebra-basilar artery
memory
neuropsychology
