摘要
目的:探讨盐酸阿比朵尔多层缓释片的研制及体内外释药评价,为盐酸阿比朵尔多层缓释片的药效学研究提供实验依据。方法:以自制的盐酸阿比朵尔多层缓释片为实验组,以盐酸阿比朵尔单方片剂为对照组,采用高效液相色谱法(HPLC)测定两组实验的体内外释放度,并计算药动学参数及相对生物利用度。结果:盐酸阿比朵尔多层缓释片与盐酸阿比朵尔单方片剂比较,峰浓度Cmax显著降低(P<0.01),达峰时间Tmax明显后移(P<0.01),吸收半衰期T1/2ka和消除半衰期T1/2ke明显延长(P<0.01),峰面积AUC(0-10)显著增加(P<0.01),药物体内平均滞留时间MRT明显延长(P<0.01);其药效可维持12 h以上,相对生物利用度为189.3%。结论:盐酸阿比朵尔多层缓释片制备工艺简单,稳定性好,药效持久,符合设计要求。
Objective To study the development of Arbidol hydrochloride（Ahyd） multi-layers controlled-released preparation and evaluate its release rate in order to provide the basis for Ahyd pharmacodynamics reseach.Methods Ahyd multi-layers was used as experiment group and Ahyd single-layer as control,high performance liquid chromatography（HPLC） was used to examine releasing level of two groups for calculating parameters of drug metabolism and bioavailability.Results Compared with Ahyd single-layer,the multi-layers controlled-released preparation had several significant advantages as below：Cmax fell remarkably（P〈0.01）;Tmax,T1/2ka,T1/2ke,AUC（0-10） and（MRT） increased（P〈0.01）.The multilayers preparation could maintain 12 h,its relative bioavailability reached 189.3%.Conclusion The multi-layers controlled-released preparation of Ahyd has simple technique,better stability and permanent effect,all of which have met designed requirements.
出处
《吉林大学学报（医学版）》
CAS
CSCD
北大核心
2009年第4期758-761,共4页
Journal of Jilin University：Medicine Edition
基金
吉林省科技厅科研基金资助课题(20070412)
关键词
盐酸阿比朵尔
多层缓释片
释放度
arbidol hydrochloride
multi-layers controlled-released preparation
release rate
