摘要
目的:测定自制的制霉菌素口腔双层贴膜在口腔内释药过程。方法:采用剩余量法测定制霉菌素口腔双层贴膜在口腔内释药情况,测定制霉菌素口腔双层贴膜体外释放度,并比较体内外释放的相关性。结果:体外释放方程:ln(100-Q)=-0.089t+4.998,r=0.997 0,口腔内释药方程为ln(100-P)=-0.022t+5.014,r=0.993 5。以体内平均释放百分率(Y,%)对体外平均释放百分率(X,%)回归,得方程Y=0.990X+0.372,r=0.998 0。结论:体内外释放度具有良好的相关性,可以用体外释放度来预测药物的释放。
Objective： To determine the oral drug release property in oral cavity of self-made nystatin buccal double-layer films.Method： The oral drug release in oral cavity of nystatin buccal double-layer films was detected by the residual quantity method,and the release in vitro was determined.The correlation of the release rate in vivo and in vitro was compared.Result： The equation of drug release in vitro was ln（100-Q）=-0.089t＋4.998（r=0.997 0）,and that of drug release in vivo was ln（100-P）=0.022t＋5.014（r=0.993 5）.The regression equation of average release rate in vivo（Y%） and the average release rate in vitro（X%） was Y=0.990X＋0.372（r=0.998 0）.Conclusion： The release rate in vivo and in vitro have a good correlation and the release rate in vitro can be used to predict the drug release in vivo.
出处
《中国药师》
CAS
2012年第10期1423-1425,共3页
China Pharmacist
关键词
制霉菌素
剩余量法
释放度
Nystatin
Residual quantity method
Release rate
