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CD44V6和P27与大肠癌关系的研究进展 被引量：2

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摘要 大肠癌是我国常见的恶性肿瘤，死亡率较高，大肠癌侵袭转移的发生是导致患者死亡的主要原因。粘附分子在肿瘤浸润和转移中的重要地位引起人们的关注^[1]。其中CD44作为透明质酸受体的一种跨膜糖蛋白，尤其是剪接变异体CD44V6的表达与大肠癌发生、发展、转移的关系已日益为许多科研工作者所重视，CD44V6已作为研究公认的肿瘤转移相关基因^[2]。最近发现，在大肠癌中存在细胞周期调节机制的异常，越来越多的证据证实，
作者 王立平 薛承岩 胡大为
机构地区 承德医学院附属医院
出处 《承德医学院学报》 2009年第3期311-314,共4页 Journal of Chengde Medical University
关键词 大肠癌 CD44V6 P27
分类号 R735.3 [医药卫生—肿瘤]
  • 相关文献

参考文献26

  • 1Harada N,Mizoi T,Kinouchi M,et al.Introduction of antisense CD44S CDNA down-regulates expression of overall CD44 isoforms and inhibits tumor growth and metastasis in highly metastatic colon carcinoma ceils [J]. Int J Cancer,2001, 91 ( 1):67 -75.
  • 2Mulder JW,Kruyt PM,Sewoath M,et al.Colorectal cancer prognosis and expression of exon-v6-containing CD44 proteins[J].Lancet, 1994,344:1470-1472.
  • 3Kawana H,Tamaru J,Tanaka T, et al.Role of P27Kipl and cyclin-dependent kinase 2 in the proliferation of non-small cell lung cancer[J].Am J Pathol, 1998,153 (2): 505-513.
  • 4Dammrich J,Vollmers HP, Heider KH,et al.Importance of different CD44V6 expression in human gastric intesti- nal and diffuse type cancers for metastatic lymphogenic soreading[J].J Mol Med,1995,73(8):395-401.
  • 5王莉.CD44基因与大肠癌[J].国外医学（肿瘤学分册）,1997,24(1):48-49. 被引量：10
  • 6Stamenkovic I,Amiot M,Pesando JM,et al.A lymphocyte molecule implicated in lymphnode homing is a member of the cartilage link protein family[J].Cell, 1989, 56(6): 1057-1062.
  • 7Gunthert U,Hofmann M,Rudy W,et al.A new variant of glycoprotein CD44 confers metastatic potential to rat carcinoma cells[J].Cell, 1991,65(5): 13-24.
  • 8Screaton GR,Bell MV,Bell JI,et al.The identification of a new alternative exon with highly restricted tissue expression in transcripts encoding the mouse Pgp-1 (CD44) homing receptor. Comparison of all 10 variable exons between mouse,human,and rat[J].J Biol Chem, 1993,268(17): 12235-12238.
  • 9Cunningham CC.Actin structural proteins in cell motility [J].Cancer Matstasis Rev, 1992,11 ( 1): 69-77.
  • 10Dall P,Heider KH,Sinn HP,et al.Comparison of immunohistochemistry and RT-PCR for detection of CD44v- expression,a new prognostic factor in human breast cancer[J1 .Int J Cancer, 1995,60(4) :471-477.

二级参考文献30

  • 1[1]Bourrguignon LY, Lida N, Welsh CF, et al. Involvement of CD44 and its variant isoforms in membrane-cytoskeleton interaction cell adhesion and tumor metastasis [J ]. J N euro Oncol, 1995,26 ( 3 ): 201.
  • 2[2]Kim H, Yang XL, Rosada C, et al. CD44 expression in colorectal adenomas is an early event occurring prior to K-ras and p53 gene mutation [J ]. Arch Biochem Biophys, 1994,310(2) :504.
  • 3[3]Coppola D,Hyacinthe M,Fu L,et al. CD44V6 expression in human colorectal carcinoma2[J ]. Hum Pathol, 1998,29(6) :627.
  • 4[4]Weg-Remers S, Anders M,Von Lampe B,et al. Decreased expression of CD44 splicing variants in advanced colorectal carcinomas[J ]. Eur J Cancer, 1998,34(10): 1607.
  • 5[5]Neumayer R, Rosen HR,Reiner A,et al. CD44 expression in benign and malignant colorectal polyps[J ]. Dis Colon Rectum, 1999,42(1 ): 50.
  • 6[6]Mulder JW,Kruyt PM,Sewnath M,et al. Colorectal cancer prognosis and expression of exon-v6-containing CD44 proteins[J ]. Lancet, 1994,344(8935): 1470.
  • 7[7]Wielenga VJ ,Heider KH,Offerhaus GJ ,et al. Expression of CD44 variant proteins in human colorectal cancer is related to tumor progression[J ]. Cancer Res, 1993,53(20):4754.
  • 8[8]lshida T . lmmunohistochemical expression of the CD44 variant 6 in colorectal adenocarcinoma[J ]. Surg Today,2000,30(1) :28.
  • 9[9]Gotley DC, Fawcett J, Walsh MD, et al. Alternatively spliced variants of the cell adhesion molecule CD44 and tumour progression in colorectal cancer[J ]. Br J Cancer,1996,74(3) :342.
  • 10Rudzki Z,Jothy S.CD44 and the adhesion of neoplastic cells[J].J Clin Pathology Mol Pathol,1997,150:57.

共引文献35

同被引文献10

引证文献2

二级引证文献7

承德医学院学报
2009年 第3期

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