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Nogo在中枢神经损伤再生中的作用机制 被引量：7

Mechanism of Nogo during regenerating in the lesioned central nervous system
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摘要 Nogo是中枢神经系统(CNS)少突胶质细胞分泌的一种髓磷脂蛋白,它的主要功能是抑制损伤后轴突的再生,它含有两个完全独立的具有抑制活性的结构域:位于细胞内的amino-Nogo和位于细胞表面的Nogo-66。Nogo-66是通过与受体复合体NgR/p75/Lingo-l结合,触发Rho信号通路来发挥作用。Nogo及其信号转导机制日益成为CNS损伤再生的研究热点,就Nogo在CNS损伤再生中的作用机制作一综述。 Nogo is a myelin-associated protein that has been shown to inhibit axonal sprouting after lesions to the central nervous system （CNS）. Two distinct inhibitory regions of Nogo-A have been identified： amino-Nogo and Nogo-66. Nogo-A and its receptors, especially Nogo-66 receptor （NgR）, p75 neurotrophin receptor （p75NTR）, and LINGO-1 increasingly became the hot topic in the study of lesioned CNS. The present research on mechanism of Nogo in the lesioned CNS was simply introduced in this review.
作者 黄海珍 桑锋 王玉霞 姚静 鲁亚平
机构地区 安徽师范大学生命科学学院
出处 《生物学杂志》 CAS CSCD 2009年第4期61-64,共4页 Journal of Biology
关键词 NOGO NOGO受体 抑制因子 神经再生 Nogo Nogo receptor inhibitor nerve regeneration
分类号 Q954.2 [生物学—动物学]
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参考文献23

  • 1王永堂,鲁秀敏,曾琳,高洁,伍亚民.Nogo及其受体在脊髓损伤修复中的作用机制[J].中国康复理论与实践,2007,13(11):1008-1010. 被引量：7
  • 2Ming WANG Ying HAN Xiao-Pan ZHANG Ya-Ping LU.Nogo,a star protein in reticulon family[J].Neuroscience Bulletin,2006,22(3):183-186. 被引量：5
  • 3Yan R, Shi Q, Hu X, et al. Reticulon proteins : emerging players in neurodegenerative diseases[J]. Cell Mol Life Sci, 2006, 63 : 877 - 889.
  • 4Oerthle T, van der Haar M E, Bandtlow C E,' et al. Nogo-A inhibits neurite outgrowth and cell spreading with three discrete regions [ J ]. Neurosci, 2003, 23:5393 -5406.
  • 5Oertle T, Huber C, Vanderputten H, et al. Genomic structure and functional characterization of the promoters of human and mouse nogo/rtn4 [ J ]. J MolBiol, 2003, 325 (2) :299 - 323.
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  • 7Fournier A E, GrandPre T, Strittmatter S M. Identification of a receptor mediating Nogo-66 inhibition of axonal regeneration [ J]. Nature, 2001, 409(6818):341 -346.
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二级参考文献70

  • 1Cai D, Shen Y, De Bellard M, et al. Prior exposure to neurotrophins blocks inhibition of axonal regeneration by MAG and myelin via a cAMP-dependent mechanism[ J]. Neuron, 1999,28 ( 1 ): 89-101.
  • 2Niederost B, Oertle T, Fritsche J, et al. Nogo-A and myelin-associated glycoprotein mediate neurite growth inhibition by antagonistic regulation of RhoA and Racl[J] .J Neurosci,2002,22(23): 10368-10376.
  • 3Fournier AE, Grandpre T, Strittmatter SM. Identification of a receptor mediating Nogo-66 inhibition of axonal regeneration[J]. Nature, 2001,409(6818) :341-346.
  • 4Wang KC, Kim JA, Sivasankaran R. p75 interacts with the Nogo receptor as a co-receptor for Nogo, MAG and OMgp [ J ]. Nature, 2002, 420(6911) :74-78.
  • 5Park JB, Yiu G, Kaneko S, et al. A TNF receptor family member,TROY,is a coreceptor with Nogo receptor in mediating the inhibitory activity of myelin inhibitors[ J] .Neuron,2005,45(3):345-351.
  • 6Oertle T, van der Hanr ME, Bandtlow CE. Nogo-A inhibits neurite outgrowth and cell spreading with three discrete regions[J]. J Neurosci,2003,23 (13): 5393-5406.
  • 7Hasegawa Y, Fujitani M, Hata K, et al. Promotion of axon regeneratior by myelin-associated glycoprotein and Nogo through divergent signals downstream of Gi/G[ J] .J Neurosci ,2004,24(30) :6826-6832.
  • 8Bandtlow CE,Loschinger J.Developmental changes in neuronal responsiveness to the CNS myelin-associated neurite growth inhibitor NI-35/250.Eur J Neurosci 1997,9:2743-2752.
  • 9Bandtlow CE,Dlaska M,Pirker S,et al.Increased expression of Nogo-A in hippocampal neurons of patients with temporal lobe epilepsy.Eur J Neurosci 2004,20:195-206.
  • 10Dupuis L,Gonzalez de Aguilar JL,di Scala F,et al.Nogo provides a molecular marker for diagnosis of amyotrophic lateral sclerosis.Neurobiol Dis 2002,10:358-365.

共引文献16

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生物学杂志
2009年 第4期

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