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Nogo,a star protein in reticulon family 被引量：5

Nogo,a star protein in reticulon family
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摘要 Nogo is widely expressed in higher vertebrate animals. Nogo gene gives rise to multiple isoforms. All the subtypes of Nogo proteins are characterized by a 200-amino-acid C-terminal domain, including two long hydrophobic sequences. Biological functions of Nogo include inhibition of neurite growth from the cell surface via specific receptors, intracellular trafficking, cell division and apoptosis. Here, we briefly review the elementary structure, taxonomic distribution and tissue expression of Nogo, summarize recent discoveries about localization of Nogo and mechanism of action, and discuss the possible functions of Nogo. Nogo is widely expressed in higher vertebrate animals. Nogo gene gives rise to multiple isoforms. All the subtypes of Nogo proteins are characterized by a 200-amino-acid C-terminal domain, including two long hydrophobic sequences. Biological functions of Nogo include inhibition of neurite growth from the cell surface via specific receptors, intracellular trafficking, cell division and apoptosis. Here, we briefly review the elementary structure, taxonomic distribution and tissue expression of Nogo, summarize recent discoveries about localization of Nogo and mechanism of action, and discuss the possible functions of Nogo.
作者 Ming WANG Ying HAN Xiao-Pan ZHANG Ya-Ping LU
机构地区 Department of Biological Science
出处 《Neuroscience Bulletin》 SCIE CAS CSCD 2006年第3期183-186,共4页 神经科学通报（英文版）
基金 This work was supported by the National Natural Science Foundation of China （No. 30470537） Natural Science Foundation of Department of Education, Jiangsu Provice （2005kj028zd） The Key Lab Science Foundation of Jiangsu Province.
关键词 NOGO reticulon homology domain Nogo-66 receptor APOPTOSIS REGENERATION Nogo reticulon homology domain Nogo-66 receptor apoptosis regeneration
分类号 Q426 [生物学—神经生物学] R338.2 [医药卫生—人体生理学]
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参考文献37

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  • 2Wang KC,Koprivica V,Kim JA,et al.Oligodendrocyte-myelin glycoprotein is a Nogo receptor ligand that inhibits neurite outgrowth.Nature 2002,417:941-944.
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同被引文献33

  • 1熊南翔,赵洪洋,张方成,朱长庚,朱贤立.钙离子参与Nogo-A抑制轴突生长的作用[J].解剖学报,2005,36(6):582-585. 被引量：7
  • 2孙红辉,杨有庚,王东生,白云深.小发夹RNA抑制Nogo基因表达促进脊髓损伤修复的实验研究[J].中华神经医学杂志,2007,6(2):141-143. 被引量：6
  • 3Yan R, Shi Q, Hu X, et al. Reticulon proteins : emerging players in neurodegenerative diseases[J]. Cell Mol Life Sci, 2006, 63 : 877 - 889.
  • 4Oerthle T, van der Haar M E, Bandtlow C E,' et al. Nogo-A inhibits neurite outgrowth and cell spreading with three discrete regions [ J ]. Neurosci, 2003, 23:5393 -5406.
  • 5Oertle T, Huber C, Vanderputten H, et al. Genomic structure and functional characterization of the promoters of human and mouse nogo/rtn4 [ J ]. J MolBiol, 2003, 325 (2) :299 - 323.
  • 6Huber A B, Weinmann O, Brosamle C, et al. Patterns of Nogo mRNA and protein expression in the developing and adult rat and after CNS lesions[J].J Neurosei, 2002, 22 (9) :3553 - 3567.
  • 7Fournier A E, GrandPre T, Strittmatter S M. Identification of a receptor mediating Nogo-66 inhibition of axonal regeneration [ J]. Nature, 2001, 409(6818):341 -346.
  • 8Hunt D, Mason M R, Campbell G, et al. Nogo receptor mRNA expression in intact and regenerating CNS neurons [ J]. Mol Cell Neurosei, 2002, 20(4): 537 -552.
  • 9Kim J E, Li S, Grandpre T et al. Axon regeneration in young adult mice lacking Nogo-A/B [ J ]. Neuron, 2003, 38 : 187 - 199.
  • 10Fouad K, Klusman I, Schwab M E. Regenerating corticospinal fibersin the Marmoset ( Callitrix jacchus) after spinal cord lesion and treatment with the anti-Nogo-A antibody IN-1[J].Eur J Neurosci, 2004, 20:2479 - 2482.

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Neuroscience Bulletin
2006年 第3期

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