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Nogo与Nogo受体研究 被引量：3

Nogo and Nogo Receptor
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摘要 nogo是新近发现的一种基因 ,编码 3种蛋白质 :Nogo A、Nogo B和Nogo C .迄今为止 ,已证明它有抑制成熟中枢神经系统 (CNS)神经元轴突再生及诱导细胞凋亡的作用 .Nogo受体是一种糖基醇磷脂结合蛋白 .对Nogo和Nogo受体的研究 ,对于CNS再生障碍及肿瘤的认识和治疗有重要意义 . nogo is a recently discovered gene. It mainly encodes three proteins: Nogo A, Nogo B and Nogo C. To date, it has been proved to be associated with axonal outgrowth inhibition in mature central nervous system(CNS) and apoptosis inducing. Nogo receptor is a glycosylphosphatidylinositol(GPI) anchored protein. To investigate the Nogo and Nogo receptor is important for understanding of neurite outgrowth inhibition following CNS injury and cancer.
作者 吴兰香 孙长凯 范明
机构地区 大连医科大学脑疾病研究所 军事医学科学院基础医学研究所
出处 《生物化学与生物物理进展》 SCIE CAS CSCD 北大核心 2002年第6期834-836,共3页 Progress In Biochemistry and Biophysics
关键词 NOGO受体 神经再生 细胞凋亡 neural regeneration, apoptosis, Nogo, Nogo receptor
分类号 Q75 [生物学—分子生物学]
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参考文献5

  • 1[1]Woolf C J, Bloechlinger S. It takes more than two to Nogo.Science, 2002, 297 (5584): 1132～ 1134
  • 2[2]Ng C E, Teng B L. Nogos and the nogo-66 receptor: factors inhibiting CNS neuron regeneration. J Neurosci Res, 2002, 67(5): 559～565
  • 3[3]Li Q, Qi B, Oka K, et al. Link of a new type of apoptosisinducing gene ASY/Nogo-B to human cancer. Oncogene, 2001,20 (30): 3929～3936
  • 4[4]Grandpre T, Li S, Strittmatter S M. Nogo-66 receptor antagonist peptide promotes axonal regeneration. Nature, 2002, 417(6888): 547～551
  • 5[5]Papadopoulos C M, Tsai S Y, Alsbiei T, et al. Functional recovery and neuroanatomical plasticity following middle cerebral artery occlusion and IN-1 antibody treatment in the adult rat. Ann Neurol, 2002, 51 (4): 433～441

同被引文献22

  • 1谢琳,贺翔鸽,何凤慈,马建洲,龙在云,王永堂,刘媛.Nogo-66受体在大鼠神经组织中的表达[J].第三军医大学学报,2005,27(23):2335-2337. 被引量：7
  • 2Morgan JE. Optic nerve head structure in glaucoma: astrocytes as mediators of axonal damage. Eye 2000; 14:437-44.
  • 3Tezel G,Hernandez MR,Wax MB.In vitro evaluation of reactive astrocyte migration,a component of tissue remodeling in glaucomatous optic nerve head.Glia 2001 ;34:178-89.
  • 4Levkovitch-Verbin H, Quigley HA, Martin KR, et al. Translimbal laser photocoagulation to the trabecular meshwork as a model of glaucoma in rats.Invest Ophthalmol Vis Sci 2002; 43:402-10.
  • 5Chen MS, Huber AB, van der Haar ME, et al. Nogo-A is a myelin-associated neurite outgrowth inhibitor and an antigen for monoclonal antibody IN-1.Nature 2000;403:434-9.
  • 6Goldberg JL, Barres BA. Nogo in nerve regeneration. Nature 2000;403:369-70.
  • 7Eddleston M, Mucke L. Molecular profile of reactive astrocytes-implications for their role in neurologic disease. Neuroscience 1993;54(1):15-36.
  • 8Anderson DR, Davis EB. Sensitivities of ocular tissues to acute pressureinduced ischemia. Arch Ophthalmol 1975 ;93:267-74.
  • 9Morrison JC, Dorman-Pease ME, Dunkelberger GR, et al. Optic nerve head extracellular matrix in primary optic atrophy and experimental glaucoma. Arch Ophthalmol 1990; 108:1020-4.
  • 10Park SH,Park JW, Park SJ,et al. Apoptotic death ofphotoreceptors in the streptozotocin-induced diabetic rat retina[J]. Diabetologia,2003,46(9).1260-1268.

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生物化学与生物物理进展
2002年 第6期

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