摘要
微波辐射无溶剂下,以碘化锌为催化剂,以芳香醛、苯偶酰、乙酸铵为原料,经多组分"一锅法"高效地合成了10种2-芳基-4,5-二苯基咪唑衍生物。通过实验得出最佳反应条件是:催化剂为碘化锌,用量0.15mmol,微波辐射功率400W,反应时间5min,最高产率可达96%。与传统合成方法相比,本法快捷、简便、高效、环境友好且催化成本低。
The synthesis of ten 2-aryl-4,5-diphenyl-1H-imidazoles by three-component reaction of aromatic aldehydes, benzil and ammonium acetate catalyzed by zinc iodide under microwave irradiation and solvent-free conditions were achieved. The optimum operation conditions were obtained by experiment, as follows： the catalyst is zinc iodide, the amount of catalyst is 0.15mmol, irradiation power 400W, reaction time 5min, under these conditions, the yield is up to 96%. High yield, inexpensive catalyst are the advantages of this process.
基金
国家自然科学基金项目(20572086)
