摘要
目的:观察老年冠心病(ECHD)患者冠状动脉血流储备(CFR)的变化及阿托伐他汀治疗后的影响。方法:应用彩色多普勒超声仪检测30例ECHD患者及35例健康志愿者中CFR,化学发光法测定2组血清总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、血浆内皮素-1(ET-1),且对治疗前后上述各项指标进行比较。结果:ECHD患者治疗前的TC、LDL-C及ET-1水平显著高于对照组(P<0.01),CFR低于对照组(P<0.01);经阿托伐他汀治疗8个月后,TC、LDL-C及ET-1水平均明显降低(P<0.05),而CFR明显升高(P<0.05)。结论:阿托伐他汀治疗可有效降低ECHD患者TC、LDL-C及ET-1水平,从而改善患者的CFR。
OBJECTIVE To investigate the change of coronary flow reserve （CFR） in elderly patients with coronary heart disease （ECHD） and the effect on CFR treated with atorvastatin. METHODS CFR was detected in 30 ECHD patients and 35 healthy controls by color Doppler. And the total cholesterol （TC）, low-density lipoprotein cholesterol （LDLC）, triglyceride （TG） and endothelin 1 （ET-1） were detected by chemiluminescence. Compared the level of TC,LDL-C,TG and ET 1 and the change of CFR between pre-and post therapy with atorvastatin. RESULTS The level of TC, LDL-C and ET-1 in treatment groups was higher than in the healthy groups（P〈0. 01 ） and the CFR in the treatment groups was lower than in the healthy groups（P〈0. 01 ）. The level of TC, LDI/C and ET-1 significantly decreased（P〈0. 05） and the CFR significantly inereased（P 〈0. 05） in 8 months treated with atorvastatin. CONCLUSION The level of TC, LDDC of ECHD may be effectively decreased by treading with atorvastatin, and the CFR of ECHD could be improved.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2009年第16期1375-1377,共3页
Chinese Journal of Hospital Pharmacy
关键词
阿托伐他汀
冠心病
冠脉血流储备
atorvastatin
coronary heart disease
coronary flow reserve
