摘要
目的 应用彩色多普勒超声仪检测冠状动脉血流储备 (coronaryflowreserve ,CFR) ,初步观察老年糖尿病患者中CFR的变化。方法 2 5例老年糖尿病患者及 2 5例健康志愿者作对照组 ,比较两组的空腹血糖 (FBG)、早餐后 2h血糖 (P2hBG)、糖化血红蛋白A1c (HbA1c)、总胆固醇 (TC)、低密度脂蛋白胆固醇 (LDL C)及甘油三酯(TG)、内皮素 1(ET 1)、静息状态时患者冠状动脉的基础血流速度 (bFV)、潘生丁注射后的最大冠脉血流速度(mFV)及CFR。结果 糖尿病组的FBG、P2hBG、TG及ET 1水平显著高于对照组 [分别为 :(9 1± 3 3)mmol/L与 (5 3± 0 7)mmol/L ;(15 8± 5 0 )mmol/L与 (8 5± 2 4 )mmol/L ;(2 96± 0 5 6 )与 (1 6 9± 0 82 )mmol/L及(15 3 80± 13 5 0 )ng/L与 (76 2 3± 10 78)ng/L ,均P <0 0 1],糖尿病组静息时的基础冠脉血流速度 (bFV)及TC、LDL C水平与对照组比较 ,差异均无显著性意义 (均P >0 0 5 ) ,而潘生丁注射后mFV及CFR (CFR =mFV/bFV)较对照组明显下降 [分别为 (5 8 1± 7 9)cm/s与 (73 5± 9 8)cm/s及 2 31± 0 4 9与 3 5 8± 0 4 6 ,P均 <0 0 1]。结论 老年糖尿病患者冠状动脉血流储备明显下降。
Objective To evaluate the coronary flow reserve in patients with elderly diabetes by color Doppler ultrasound. Methods Twenty-five healthy subjects as control group and 25 elderly diabetes patients were studied. The concentrations of fast blood glucose (FBG), 2-h-post-breakfast blood glucose (P2hBG), glycosylation hemoglobin A1c (HbA1c), total cholesterol (TC), low density lipid cholesterol (LDL-C), triglyceride (TG), endothelin-1 (ET-1) and coronary flow reserve (CFR=mFV/bFV) were measured and compared between the two groups. Results The concentrations of FBG, P2hBG, TG and ET-1 in diabetes group were much higher than those in control group \[(9.1±3.3) mmol/L vs (5.3±0.7) mmol/L; (15.8±5.0) mmol/L vs (8.5±2.4) mmol/L; (2.96±0.56) mmol/L vs (1.69±0.82) mmol/L and (153.80±13.50) ng/L vs (76.23±10.78) ng/L, P<0.01, respectively\]. There was no significant difference in the basal coronary flow velocity (bFV) and the concentrations of TC and LDL-C between diatetes group and control group. After infusion of dipyridamole, the maximal coronary flow velocities and the CFR in diabetes group were lower than those in control group \[(58.1±7.9) cm/s vs (73.5±9.8) cm/s and (2.31±0.49) vs (3.58±0.46), all P<0.01\]. Conclusion The coronary flow reserve and endothelium function in elderly diabetes patients were greatly damaged.
出处
《华中科技大学学报（医学版）》
CAS
CSCD
北大核心
2004年第3期369-371,共3页
Acta Medicinae Universitatis Scientiae et Technologiae Huazhong
基金
湖北省"九五"重点科技攻关项目 (No .95 2P110 1)
