摘要
目的:研究早期应用阿托伐他汀和降纤酶对不稳定型心绞痛(UAP)伴高胆固醇血症患者冠状动脉(冠脉)血流储备(CFR)的影响。方法:60例UAP伴高胆固醇血症患者随机均分为治疗组和对照组,经胸彩色多普勒冠状血流显像技术检测CFR,比较治疗前后血脂及CFR的变化。结果:阿托伐他汀联用降纤酶治疗后血清总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、三酰甘油(TG)均明显降低(P<0.01),CFR由治疗前1.92±0.41升至2.97±0.62(P<0.01)。结论:阿托伐他汀联用降纤酶可以改善UAP患者的冠脉微循环,提高CFR。
Objective：To investigate the effects of cholesterol-lowerlng therapy with atorvastain and defibrase on coronary flow reserve （CFR） in patients with unstable angina pectories（UAP） and hypercholesterolemia.Method：Sixty patients with UAP were randomly divided into atorvastain therapeutic group （n=30） and conventional therapeutic group （n=30）.By using color Doppler ultrasound, the coronary flow reserve was measureed in patients with UAP before and after 3 months choles- terol-lowering therapy.Results：After cholesterol-lowlng therapy for 3 months,the serum total cholesterol （TC）,low desity lipoprotein cholesterol （LDL-C）,triglyceride （TG） decreased significantly （P〈0.01）.The coroary flow reserve was increased from 1.92±0.41 to 2.97±0.62 （P〈0.01）. An inverse correlation was found not only between TC and CFR （r=-0.44,P〈0.05）, but also between LDL-C and CFR （r=-0.47,P〈0.05）.Conclusion：Cholesterol-lowering therapy with atorvastain may improve coronary flow reserve in patients with UAP and hypercholesterolemia.
出处
《中国医药导报》
CAS
2007年第02X期12-13,共2页
China Medical Herald
