摘要
半乳凝素3(galectin3,Gal-3)是一种相对分子质量为29-35kDa的基因产物,包含已报道的14种成员的糖结合蛋白家族的一员,主要存在于细胞质中,也可易位到核膜,细胞核并且分泌到细胞外基质中.Gal-3参与细胞生长、增殖、分化、黏附,炎症和免疫应答,血管发生、凋亡以及肿瘤的进展和转移,并且是糖基化终产物受体之一.近年来人们开始关注Gal-3与各种肝脏疾病之间的关系,如脂肪肝、肝纤维化、肝硬化和肝癌.本文就此作一综述.
Galectin-3, having an apparent molecular weight between 29 and 35 kDa, is a member of a galectin family of mammalian carbohydratebinding proteins consisting so far of 14 reported members. Galectin-3 is predominantly localized in the cytoplasm and may translocate to the perinuclear membrane, nucleus and get secreted into the extracellular matrix （ECM）. It is involved in cell growth, proliferation, differentiation and adhesion, immune responses, angiogenesis, apoptosis, and tumor progression and metastasis. Furthermore, galectin-3 can act as a receptor for advanced glycation end-products. Recent studies have shown that galectin-3 is associated with many hepatic diseases, such as fatty liver disease, hepatic fibrosis, cirrhosis and liver cancer. Here, we will review the relationship between galectin-3 and hepatic diseases.
出处
《世界华人消化杂志》
CAS
北大核心
2009年第19期1909-1912,共4页
World Chinese Journal of Digestology
关键词
半乳凝素3
肝脏疾病
脂肪肝
肝癌
Galectin-3
Liver disease
Fatty liwe
Liver cancer
