摘要
由L-半胱氨酸乙酯与二硫化碳在Et3N存在下反应，得到光学活性（R）－四氢噻唑－2－硫酮－4－羧酸乙酯，后者同3－（2－氧代环已基）丙酸在N，N－二环己基胺二亚胺（DCC）存在下反应，得到光学活性（R）－N－3－（2－氧代环己基）丙酰四氢噻唑2－硫酮－4－羧酯乙酯及光学活性的3－（2－氧代环己基）丙酸．用半经验的量子化学PM3方法研究反应物和产物的最优构型与电子结构．
(R)-thiazolidine-2-thione-4-ethyl ester was prepared by the reaction of Lteine ethyl ester with CS2 in the presence of Et3N and NiSO4 in a 79.0% yield. The optically active N3-(2-oxocyclohexyl)propionylthiazolidine-2-thione-4-carboxylic ethyl ester was synthesized from 3-(2-oxocycolhexyl)propionic acid and (R)-thiazolidine-2-thione-4-carboxylic ethyl by using dicyclohexylcarbodiimide(DCC)as the condensing agent. In the mean time optically active S-excess 3-(2-oxocycolhexyl)propionic acid was separated. The optimized conifiguration and electronic structure of the products and reactants were studied by means of molucular orbinal PM3 method.
出处
《吉林大学自然科学学报》
CSCD
1998年第3期103-106,共4页
Acta Scientiarum Naturalium Universitatis Jilinensis
基金
国家自然科学基金
关键词
四氢噻唑
硫酮
羧酸乙酯
氧代环己基
丙酸
(R)-thiazolidine-2-thione-4-carboxylic ethtl ester
(R)-N-3-(2-oxocycolhexyl)propionylthiazolidine-2-thione-4-carboxylic ethyl ester
optimized configuration
electronic sturcture
