摘要
３－（２－氧代环烷基）丙酸与（Ｒ）－２－硫代四氢噻唑－４－羧酸乙酯的反应李叶芝，田颜清，黄化民（吉林大学化学，长春，１３００２３）关键词（Ｒ）－２－硫代四氢噻唑－４－羧酸乙酯，Ｎ－３－（２－氧代环烷基）丙酰－２－硫代四氢噻唑－４－羧酸乙酯，环合反应，...
he equimolar reaction of 3-(2-oxocyclohexyl)propionic acid or 3-(2-oxocy-clopentyl) propionic acid and(R)-2-thioxothiazolidine-4-carboxyli ethyl ester (1)with N-methyl-2-chloropyridium salt in the presence of triethylamine produced the corresponding op-tically active N-3-(2-oxocycloalkyl) propionyl-2-thioxothiazolidine-4-carboxylic ethyl ester(2a) and N-3-(2-oxocyclopentyl)propionyl-2-thioazolidine-4-carboxylic ethyl ester(2b).When the molar ratio of 3-(2-oxocyclohexyl)-propionic acid to compounds 1 is 2:1,2a andS-excess 3-(2-oxocyclohexyl)propionic acid were obtained.When 2a and 2b react withracemic a-phenylethylamine(molar ratio 1:2),the photoactive compound N-3-(2-oxocyclo-hexyl)propionyl-α-phenylethylaine(5a)or N-3-(2-oxocyclopentyl)propionyl-α-phenylethyla-mine(5b)were obtained.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
1996年第1期94-96,共3页
Chemical Journal of Chinese Universities
基金
国家自然科学基金
关键词
硫代四氢噻唑
羧酸乙酯
氧代环烷基
丙酸
R)-2-Thioxothiazolidine-4-carboxylic ethyl ester,N-3-(2-Oxocycloalkyl)propi-onyl-2-thioxothiazolidine-4-carboxylic ethyl ester,Cyclization,α-Phenylethylamine
