摘要
目的探讨原发性肝癌（ＨＣＣ）组织中三种转化生长因子β（ＴＧＦβ）的表达及其与肝癌复发的关系。方法ＡＢＣ免疫组织化学方法检测５２例小肝癌患者癌组织中三种ＴＧＦβ的免疫反应性，并根据术后２年内肝癌有无复发，分析其与肝癌复发的关系。结果复发组ＴＧＦβ１表达阳性率为８５％（１７／２０），无复发组ＴＧＦβ１表达阳性率为４７％（１５／３２），两组比较差异有显著意义（Ｐ＜００５）。复发组ＴＧＦβ２阳性率５０％（１０／２０），强阳性率４０％（８／２０），无复发组ＴＧＦβ２阳性率６６％（２１／３２），强阳性１３％（４／３２），两组比较差异有显著意义（Ｐ＜００５）。复发组ＴＧＦβ３阳性率４５％（９／２０），无复发组ＴＧＦβ３阳性率６３％（２０／３２），两组比较差异无显著意义（Ｐ＞００５）。结论肝癌组织中ＴＧＦβ１。
Objective To detect the expression of three TGFβ isoforms and its clinicopathologic significance in hepatocellular carcinoma(HCC). Methods Surgical specimens of 52 patients with small HCC resection during 1992～1995 were used to determine the immunoreactivity of TGFβ protein by ABC immunohistochemistry . These specimens were divided into recurrence group(G1) and unrecurrence group(G2) according to whether HCC recurred two years after resection. The relations with recurrene of HCC were analyzed. Results The positive rates in G1 and G2 were 85%(17/20) versus 47%(15/32) for TGFβ1, 90%(18/20) vs. 78%(25/32) for TGFβ2, and 45%(9/20) vs. 63%(20/32) for TGFβ3. Significant difference was found in TGFβ1 and TGFβ2, but not in TGFβ3. Conclusion The high immunoreactivity to TGFβ1 or TGFβ2 is positively related to the recurrence of HCC.
出处
《中华医学杂志》
CAS
CSCD
北大核心
1998年第8期595-597,共3页
National Medical Journal of China
关键词
肝肿瘤
癌
转化生长因子Β
复发
Liver neoplasms Cancer Transforming growth factor β Recurrence
