摘要
目的通过检测胃癌患者血清VEGF及p53的含量,探讨VEGF和p53在胃癌中的表达与肿瘤的发生、发展、预后的关系。方法所有标本均采用深圳晶美生物公司提供的VEGFELISA试剂盒及奥地利Bend-erMedesystems公司提供的p53ELISA试剂盒进行检测。结果血清VEGF含量正常对照组为55.73±8.36pg/ml,胃癌组为201.85±92.13pg/ml,二组比较有显著性差异(P<0.001),血清p53含量正常对照组为0.16±0.04U/ml,胃癌组为0.45±0.10U/ml,二组比较有显著性差异(P<0.001)。结论通过对胃癌患者血清VEGF及p53含量的检测,可以为胃癌的诊断、治疗提供依据。
Objective： To explore the expressions of vascular endothelial growth factor（VEGF） and p53 serum level in gastric carcinoma and clinical significances. Methods： The serum levels of VEGF and p53 were detected by enzyme - linked immunosobant assays in patients with gastric carcinoma and the normal control group. Results： Serurn level of VEGF in the normal control group was 55.73 ± 8.36pg/ml, The patients group had significantly higher VEGF serum level （201.85 ±92. 13pg/ml） than the control（P 〈0.001 ）. Serum level of p53 in the normal control group was 0. 16 ±0.04U/ml, in the gastric carcinoma patients was 0.45 ±0.10U/ml, p53 levels between the two groups were significant different（ P 〈0.001 ）. Conclusion： VEGF and p53 are both involved in the pathogenesis of gastric carcinoma, the detection of VEGF and p53 serum level can help diagnose and therpy of gastric carcinoma.
出处
《现代肿瘤医学》
CAS
2007年第3期375-376,共2页
Journal of Modern Oncology
